实验性网脱复位后未脱离区域视网膜组织形态学观察

目的:研究视网膜脱离(RD)复位后未发生脱离区域的视网膜组织形态改变。方法:将20只健康成年新西兰灰兔随机分为空白对照组2只和实验组18只,实验组在显微镜下行视网膜下注射透明质酸钠建立视网膜脱离自动复位动物模型,分别于术后10d、20d、30d处死实验兔并摘除眼球进行组织学观察。结果:未发生脱离区域的视网膜在复位早期表现为色素上皮层基本正常,感光细胞层、双极细胞层排列紊乱,感光细胞、双极细胞、神经节细胞均有变性。结论:RD复位后视网膜上光感受器的不完全再生,双极细胞和神经节细胞的不可逆变化,均可影响视功能的提高。

Histomorphological changes of undetached retina after experimental retinal reuttachment

Objective: To study the possible histomorphological change of undetached retina after retinal reattachment.Methods: Twenty pigment rabbits were randomly divided into experimental group and control group.In the experimental group was retinal detachment models were produced by infusing sodium hyaluronate between neural retina and retinal pigment epithelium.Light microscopy was used to observe the undetached retinal changes after 10,20,30 postoperative days.Result :In early stage after operation,the undetached retinal pigment epithelium seemed almost normal,but the outer and inner nuclear layers showed obvious abnormality with disturbance,and the photoreceptor cells,bipolar cells,ganglion cells all showed swelling and vacuolar degeneration .The changes had not recovered after 30 days later.Conclusion : Although the retina was only going through a short time detachment,the bipolar and ganglion cells in undetached region suffered irreversible injury.These pathologic changes may affect postoperative recovery of visual function.