急性出血坏死性胰腺炎胰腺血循环障碍的实验研究

目的：探讨急性出血坏死性胰腺炎（AHNP）大鼠胰腺血循环障碍的机制,方法：用5％牛黄胆酸钠溶液胰管注入,制备AHNP模型。动态观察胰腺血流量（PBF）与大鼠,血浆中两对重要的血管活性物质血栓素A2／前列腺素I2（TXA2／PGI2）,内皮素／一氧化氮（ET／NO）及其病理变化间的内在联系。结果：AHNP大鼠PBF明显持续下降,TXA1,PGI2,ET和NO显著升高,而且TXA2／PGI2（T／P（和ET／NO（E／N）比值持续增加。结论：TXA2／PGI2和ET／NO可能是介导AHNP大鼠胰腺血循环的障碍的重要因素。

Experimental study of panceatic hemocirculatory disorder in acute hemorrhagic necrotizing pancreatitis

Objective To study the mechanism of panceatic hemocirculatory disorder in acute hemorrhagic necrotizing pancreatitis(AHNP).Methods The rat model of AHNP was estabished by injecting 5% sodium taurocholate into the bile pancreatic duct. The immanent relationship was observed that exists among panceatic blood flow(PBF)?plasma thromboxane A 2/prostaglandin I 2 (TXA 2/PGI 2 ,T/P) and endothelin/nitric oxide(ET/NO,E/N),which are two double important vasoactive matter, and pancreatic pathology.Results During AHNP, the PBF was reduced significantly continualtly, but the plasma level of TXA 2?PGI 2 ?ET and NO and ratio of T/P and E/N was progressively increased.Conclusion The increase of TXA 2?PGI 2?ETand NO level and T/P and E/N ratio in the plasma might play a key role in the pathologic changes of AHNP in rats.