克拉霉素治疗重度慢性牙周炎的效果评价

目的:观察克拉霉素对重度慢性牙周炎的治疗效果。方法:90例重度慢性牙周炎患者,随机分为3组:克拉霉素组、甲硝唑对照组和空白对照组各30例。分别比较基线、1个月、3个月时各组患者的龈沟出血指数(SBI),牙周探诊深度(PD)和附着丧失(AL)的变化。结果:(1)基线时3组PD、SBI、AL差异无统计学意义(P>0.05)。(2)在1月时检测克拉霉素组PD、SBI均低于甲硝唑组(P<0.05),AL两者差异无统计学意义(P>0.05)。(3)3月时克拉霉素组PD、AL均低于甲硝唑组(P<0.05),SBI两者差异无统计学意义(P>0.05)。(4)1月及3月时SBI、PD、AL克拉霉素组及甲硝唑组均低于空白对照组(P<0.05)。结论:克拉霉素治疗重度慢性牙周炎有良好的临床疗效。

Evaluation of the clinical effects of clarithromycin on the treatment of severe chronic periodontitis

Objective: To investigate the clinical effect of clarithromycin for the treatment of severe chronic periodontitis.Methods: 90 patients with severe chronic periodontitis were randomly divided into 3 groups: group with clarithromycin treatment,with metronidazole treatment and blank control group,30 cases per group.After 1 month and 3 months,gingival sulcus bleeding index(SBI),probing depth(PD) and attachment loss(AL) was evaluated and compared with the baseline.Results:(1) at the baseline levels,there was no significant difference statistically(P> 0.05) about all of the three indexes(PD,SBI,AL);(2) after 1 month,PD,SBI of clarithromycin group were lower than those of metronidazole group(P <0.05).There was no significant difference about AL between clarithromycin group and metronidazole group(P> 0.05);(3) after 3 month,PD,AL of clarithromycin group metronidazole group were lower than those of metronidazole group(P <0.05),whereas there was no significant difference of SBI between these two groups(P> 0.05);(4) after 1 and 3-months,SBI,PD,AL of both clarithromycin group and metronidazole group were lower those of than the control group(P <0.05).Conclusion: Clarithromycin can be used in the treatment of severe chronic periodontitis with significant clinical effects.