| 大肠癌中C—erbB—2基因扩增的研究 |
| |
| 引用本文： | 骆成玉 祝学光. 大肠癌中C—erbB—2基因扩增的研究[J]. 中国现代医学杂志, 1999, 9(5): 4-7 |
| |
| 作者姓名： | 骆成玉 祝学光 |
| |
| 作者单位： | [1]北京军区总医院普外科 [2]北京医科大学人民医院 |
| |
| 摘 要： | 应用差异ＰＣＲ技术研究了大肠癌中Ｃ－ｅｒｂＢ－２基因的扩增情况。结果发现，大肠癌组织中Ｃ－ｅｒｂＢ－２基因存在明显扩增，该基因的扩增与大肠癌组织学分级、远处转移之间均有非常显著的关联。大肠癌中随着癌组织学分级程度的加重，Ｃ－ｅｒｂＢ－２基因扩增逐渐向高、低拷贝转移，说明，Ｃ－ｅｒｂＢ－２基因扩增在一定程度上反映着大肠癌分化状态和生物学行为，可作为大肠癌患者预后的重要参数，并可指导临床治疗。
|
| 关 键 词： | 大肠肿瘤 C－erbB－2基因 基因扩增 |
THE STUDY OF THE AMPLIFICATION OF C-erbB-2 GENE IN COLORECTAL CARCINOMA |
| |
| Luo Chengyu,Zhu Xueguang,Li Shiyong,Wang Shenwu. THE STUDY OF THE AMPLIFICATION OF C-erbB-2 GENE IN COLORECTAL CARCINOMA[J]. China Journal of Modern Medicine, 1999, 9(5): 4-7 |
| |
| Authors: | Luo Chengyu Zhu Xueguang Li Shiyong Wang Shenwu |
| |
| Affiliation: | Luo Chengyu,Zhu Xueguang,Li Shiyong,Wang Shenwu. Beijing Army General Hospital,Beijing 100700,P.R.China |
| |
| Abstract: | The amplification of c-erbB-2 gene in colorectal carcinoma was studied by differential PCR technique. The results showed that the poorer the histologic was, the lower and /or higher copy of the c-erbB-2 gene amplification was transferred. The amplification was significantly higher in the patients with distant metastasis transfer than that in no-distant metastasis transfer. It suggested that the amplification of c-erbB-2 gene reflects the differentiation state and biological behavior of colorectal carcinoma to some extent. |
| |
| Keywords: | Colorectal carcinoma c-erbB-2 gene |
| 本文献已被 CNKI 维普 等数据库收录！ |
