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| 宫内生长迟缓对生后脂代谢的影响及其机制 | |
| 引用本文： | 陈联辉,梁黎. 宫内生长迟缓对生后脂代谢的影响及其机制[J]. 国际儿科学杂志, 2014, 0(4): 347-350 |
| 作者姓名： | 陈联辉 梁黎 |
| 作者单位： | 陈联辉(综述) (浙江大学医学院附属第一医院儿科, 杭州,310003)； 梁黎(审校) (浙江大学医学院附属第一医院儿科, 杭州,310003)； |
| 基金项目： | 国家自然科学基金资助项目(项目编号：81170733) |
| 摘 要： | 宫内生长迟缓（ IUGR）是妊娠期常见的并发症。流行病学和临床研究表明,IUGR对生后的脂代谢会造成长远的影响。 IUGR影响出生后的脂代谢是通过调节脂肪酸和胆固醇代谢通路中的相关信号实现的,新近的研究发现,IUGR对这些信号通路的影响可能是通过表观遗传修饰造成的。对这些表观遗传学机制的深入研究,有助于对IUGR成年后的脂代谢紊乱、非酒精性脂肪肝、代谢综合征等疾病的预防和治疗开辟新的途径。 |
| 关 键 词： | 宫内生长迟缓 表观遗传学 脂代谢 |
The role of intrauterine growth retardation on postnatal lipid metabolism and its mechanism |
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| Chen Lian-hui,Liang Li. The role of intrauterine growth retardation on postnatal lipid metabolism and its mechanism[J]. International Journal of Pediatrics, 2014, 0(4): 347-350 | |
| Authors: | Chen Lian-hui Liang Li |
| Affiliation: | (Department of Pediatrics, the First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou 310003, China.) |
| Abstract: | Intrauterine growth retardation（ IUGR） is a common complication during pregnancy. Epidemiological and clinical studies have shown that IUGR has a long-term impact on postnatal lipid metabolism. The effect of IUGR on postnatal lipid metabolism is accomplished by regulating signal pathways of fatty acid and cholesterol metabolism,which may be mediated by epigenetic modifications. Further study of these epigenetic mechanisms could lead to a novel way for prevention and treatment of adulthood diseases, including dyslipidemia,non-alcoholic fatty liver disease and metabolic syndrome. |
| Keywords: | Intrauterine growth retardation Epigenetics Lipid metabolism |
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