病毒性肝炎患者干眼症发生情况及相关因素研究

目的 分析病毒性肝炎患者干眼症患病特点.方法 收集2011年1月至2013年12月就诊于北京佑安医院眼科的病毒性肝炎患者292例（其中乙型肝炎253例、丙型肝炎39例）,进行干眼症的相关检查以及肝功能检查,包括询问病史、裂隙灯检查、角膜荧光素染色、泪膜破裂时间（BUT）检查和泪液分泌试验（schirmer test）,并检测患者丙氨酸氨基转移酶、总胆红素、白蛋白等.结果 292例病毒性肝炎患者中,干眼症208例,非干眼症患者84例.其中男性169例,干眼症者119例;女性123例,干眼症者89例.干眼症组与非干眼症组年龄分别为47±12岁、44±13岁;丙氨酸氨基转移酶中位数值分别为37.61U·l-1、27.30 U· l-1;总胆红素中位数值分别为25.26umol·l-1、15.35umol·l-1;白蛋白分别为42.72 ±6.10g·l-1、44.04 ±4.21g·l-1.其中年龄、总胆红素以及白蛋白三项,在干眼症与非干眼症患者间差异有统计学意义.在所有208例干眼症患者中乙肝177例,占85.10％;丙肝31例,占14.90％,乙型和丙型病毒性肝炎患者间干眼症患病情况无统计学差异.乙型和丙型病毒性肝炎患者Schirmer Ⅰ试验以及BUT检查结果无统计学差异.年龄及总胆红素与病毒性肝炎患者干眼症有相关性.结论 病毒性肝炎患者干眼症有其自身特点,其干眼症发生率高,且与性别无相关性,与年龄相关.乙型肝炎及丙型肝炎干眼症发生情况无统计学差异.

Occurrence and related factors analysis for dry eye syndrome in viral hepatitis patients

Objective To analyze the characteristics of dry eye syndrome in viral hepatitis patients.Methods Two hundred and ninety-two patients with viral hepatitis,including 253 cases of hepatitis B,39 cases of hepatitis C visited our department of ophthalmology and were enrolled in this study.All patients received eye examination and liver function tests,including medical history,slit lamp examination,corneal fluorescein staining,tear film break-up time （BUT） and schirmer test,alanine aminotransferase （ALT）,total bilirubin （TBil）,albumin （ALB）.Results In the 292 cases of viral hepatitis,there were 208 dry eye cases and 84 non-dry eye cases.In 169 male cases,119 cases had dry eyes; in 123 femalecases,89 cases were with dry eyes.In the dry eyes group and non-dry eyes group,the ages were 47 ± 12 and 44 ± 13 years old,respectively.The median values of alanine aminotransferase was 37.61U l-1 and 27.3U l-1; the median values of total bilirubin were 25.26umol· l-1 and 15.35umolⅠ·l-1 and albumin values were 41.81 ±6.49g l-1,43.56 ± 4.59g l-1.There were statistics difference in age,total bilirubin and albumin values between dry eye and non-dry eye groups.In the 208 hepatitis B patients,85.10% showed dry eye （177 cases） ; 14.90% of the 31 hepatitis C cases had dry eyes.There was no significant difference between the prevalence of dry eye syndrome in hepatitis B and hepatitis C viral hepatitis patients.There was no significant difference in Schirmer I test and BUT between different types of viral hepatitis.Ages and total bilirubin values were the correlation factors in viral hepatitis and dry eye.Conclusions Viral hepatitis patients with dry eye syndrome has its own characteristics,including high incidence of dry eyes in patients with viral hepatitis.Dry eye has no correlation with gender.There was no significant difference of dry eye syndrome in hepatitis B and hepatitis C patients.Age and total bilirubin values correlated with viral hepatitis and dry eye.