二氧化硅,矽肺与肺癌的关系

通过耐火材料等四个行业的接尘人员中肺癌死亡回顾性队列调查,发现接尘人员中肺癌危险性明显高于非尘毒暴露组,而且肺癌标化死亡率随含硅量及接触浓度变化呈现出平行的趋势。矽肺合并肺癌多为早期矽肺,肺癌病变多分布在肺上叶,病理形态鳞癌较多。肺癌发生晚于矽肺。吸烟和矽肺同时存在时,有必要注意协同作用。

CORRELATION OF SILICA SILICOSIS AND LUNG CANCER

Ketrospective epidemiological study on the death of lung cancer among silica dust exposed workers in Bengang refratory plant etc. shows that the relative risk of lung cancer is higher than that of the subjects unexposed to harmful dust, and the SMR or RR of lung cancer is parallel to the concentration of silica dust exposed. Most of the cases with silicosis complicated by lung cancer are in early stage. The majority of these cases are squamous cell carcinoma sited on upper lobes of the lungs. Attention must be paid on the synergic effect of smoking and silicosis in cancer complication.