Search for the PARK3 founder haplotype in a large cohort of patients with Parkinson's disease from Northern Germany |
| |
| Authors: | C KLEIN P VIEREGGE J HAGENAH M SIEBERER E DOYLE H JACOBS T GASSER X O BREAKEFIELD N J RISCH L J OZELIUS |
| |
| Institution: | Molecular Neurogenetics Unit, Massachusetts General Hospital, and Departments of Neurology and Genetics and Neuroscience Program, Harvard Medical School, Boston, Massachusetts 02114, USA;Department of Neurology, Medical University of Lübeck, 23538 Lübeck, Germany;Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany;Department of Genetics, Stanford University, Stanford, California 94305, USA |
| |
| Abstract: | A founder haplotype on chromosome 2p for autosomal dominant Parkinson's disease (PD) has been postulated for two families of Northern European descent, and a new mutation in the α-synuclein gene (Ala30Pro) has been found in a German PD family. We evaluated 85 German PD patients and 85 ethnically matched controls for shared markers on chromosome 2p and for the new α-synuclein mutation. We found no evidence for linkage disequilibrium, suggesting that the putative founder mutation on chromosome 2p is not a common cause of PD in the local population. Furthermore, no patient carried the Ala30Pro change, supporting earlier findings that mutations in the α-synuclein gene are extremely rare. |
| |
| Keywords: | |
|
|
