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| O-甲基酪氨酸对酪氨酸抑制hCG致大鼠离体黄体细胞孕酮生成的拮抗作用 | |
| 引用本文： | 高而威,程治平. O-甲基酪氨酸对酪氨酸抑制hCG致大鼠离体黄体细胞孕酮生成的拮抗作用[J]. 基础医学与临床, 1989, 0(1) |
| 作者姓名： | 高而威 程治平 |
| 作者单位： | 北京医科大学生理教研室(高而威)，哈尔滨医科大学生理教研室(程治平) |
| 摘 要： | 用孕马血清促性腺激素和hCG处理未成年雌性大鼠,在hCG注射后7天取出黄体制成黄体细胞悬浮液,孵育后用放射免疫法测定孕酮含量。实验发现,酪氨酸结合的竞争性抑制剂O—甲基酪氨酸能够翻转酪氨酸抑制hCG的致孕酮生成作用,并与所用剂量有关,如果加大酪氨酸的剂量,则可克服O-甲基酪氨酸的翻转作用。由此提示,O-甲基酪氨酸是一种酪氨酸结合位点的拮抗剂,它通过阻断酪氨酸的结合来抑制酪氨酸的作用。 |
| 关 键 词： | 酪氨酸 O-甲基酪氨酸 hCG 孕酮 黄体细胞 |
Antagonism of O-Methyl-Tyrosine to Inhibition of HCG Induced progesterone Production by Tyrosine in Rat Corpus |
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| Luteal Cells in Vitro Gao Erwei Cheng Chiping. Antagonism of O-Methyl-Tyrosine to Inhibition of HCG Induced progesterone Production by Tyrosine in Rat Corpus[J]. Basic Medical Sciences and Clinics, 1989, 0(1) | |
| Authors: | Luteal Cells in Vitro Gao Erwei Cheng Chiping |
| Abstract: | Corpus lutea were obtained from immature rats pretreated with PMSG and hCG 7 days after hCG injection. It was found from experiments of incubation of corpus luteal cells that O-methyl-tyro-sine, a competitive inhibitor for tyrosine binding, reserved the suppresive action of tyrosine on hCG-induced progesterone secretion, depending on the dose used and the reversal effect could be overcome by increasing the dose of tyrosine. It is suggested that O-methyl-tyrosine,as an antagonist for tyrosine binding sites,might inhibit tyrosine effect through blocking tyrosine binding. |
| Keywords: | tyrosine O-methyl tyrosine hCG progesterone corpus luteal cells |
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