| 霉酚酸酯及血管紧张素Ⅱ对人近端肾小管上皮细胞增殖的影响 |
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| 引用本文： | 高山林,王希柱,李小东,郭志军.霉酚酸酯及血管紧张素Ⅱ对人近端肾小管上皮细胞增殖的影响[J].中国药房,2008,19(10):754-755. |
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| 作者姓名： | 高山林 王希柱 李小东 郭志军 |
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| 作者单位： | 1. 河北医科大学附属唐山工人医院肾脏科,唐山市,063000
2. 唐山市人民医院,唐山市,063000 |
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| 摘 要： | 目的:研究霉酚酸酯(MMF)及血管紧张素Ⅱ(AngⅡ)对人肾小管上皮细胞(HK-2)增殖的影响。方法:将培养的HK-2分别用MMF及AngⅡ刺激并采用MTT法检测HK-2增殖的情况。结果:与空白对照组比较,MMF使HK-2的增殖降低(P<0·05);AngⅡ使HK-2的增殖明显增加(P<0·01);先加入MMF后再用AngⅡ刺激HK-2,HK-2增殖低于AngⅡ单用组(P<0·01)。结论:MMF能够抑制HK-2增殖及抑制AngⅡ引起的人肾小管上皮细胞的增殖。
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| 关 键 词： | 霉酚酸酯 血管紧张素Ⅱ 肾小管上皮细胞 细胞增殖 |
| 文章编号： | 1001-0408(2008)10-0754-02 |
| 修稿时间： | 2007年11月5日 |
Effects of Mycophenolate Mofetil and AngⅡon Proliferation of Human Tubular Epithelial Cells |
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| GAO Shan-lin,WANG Xi-zhu,LI Xiao-dong,GUO Zhi-jun.Effects of Mycophenolate Mofetil and AngⅡon Proliferation of Human Tubular Epithelial Cells[J].China Pharmacy,2008,19(10):754-755. |
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| Authors: | GAO Shan-lin WANG Xi-zhu LI Xiao-dong GUO Zhi-jun |
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| Institution: | GAO Shan-lin, LI Xiao-dong, GUO Zhi-jun, WANG Xi-zhu(1.Dept. of Nephrology, Tangshan Worker＇s Hospital Affiliated to Hebei Medical University, Tangshan 063000, China;2.Tangshan Municipal People＇s Hospital, Tangshan 063000, China) |
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| Abstract: | OBJECTIVE： To evaluate the effects of mycophenolate mofetil（MMF） and Ang Ⅱ on proliferation of human tubular epithelial cells. METHODS： The cultured HK - 2 cells were stimulated by MMF and Ang Ⅱ , respectively, and the proliferation of HK -2 was assayed by MTT. RESULTS： As compared with control group, MMF inhibited the proliferation of HK- 2（P〈0.05） while Ang Ⅱ significantly promoted the proliferation of HK- 2（P（0.01） . The proliferation of human tubular epithelial cells treated by MMF before being promoted by Ang Ⅱ was significantly decreased as compared with Ang Ⅱ group（P〈 0.01）, CONCLUSION： MMF can inhibit the proliferation of HK- 2 as well as proliferation of human renal tubular epithelial cells induced by Ang Ⅱ . |
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| Keywords: | Mycophenolate mofetil Ang Ⅱ Renal tubular epithelial cells Cell proliferation |
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