Affiliation: | 1. Peninsula NIHR Clinical Research Facility, Peninsula Medical School, University of Exeter, , Exeter, UK;2. Department of Molecular Genetics, Royal Devon & Exeter NHS Foundation Trust, , Exeter, UK;3. Department of Biochemistry, Royal Devon & Exeter NHS Foundation Trust, , Exeter, UK;4. Wellcome Trust Clinical Research Facility, Birmingham Children's Hospital, , Birmingham, UK;5. Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, , Cambridge, UK;6. Wellcome Trust Clinical Research Facility, Birmingham Children's Hospital School of Clinical and Experimental Medicine College of Medical and Dental Sciences, University of Birmingham, , Birmingham, UK |