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| 多抗甲素对T—56细胞生长代谢的影响 | |
| 引用本文： | 王玉明 王玉芬. 多抗甲素对T—56细胞生长代谢的影响[J]. 中国抗生素杂志, 1993, 18(1): 55-58 |
| 作者姓名： | 王玉明 王玉芬 |
| 作者单位： | 成都军医学校生化教研室，华西医科大学药理教研室，华西医科大学生物学与细胞生物学教研室，华西医科大学药理教研室 成都610083 |
| 摘 要： | 采用同位素前体参入、液体闪烁计数、生长曲线及细胞活力测定等方法,初步证实多抗甲素能抑制T-56细胞的生长代谢,使其生长曲线下降,群体倍增时间延长,最大增殖倍数和饱含密度降低。说明多抗甲素具有一定程度的直接抗癌效应。多抗甲素抑制T-56细胞生长代谢的机制可能与其抑制RNA合成,扰乱核酸代谢有关。 |
| 关 键 词： | 多抗甲素 T－56细胞 同位素 |
EFFECTS OF POLYACTIN A ON THE GROWTH OF THE HUMAN TONGUE SQUAMOUS CARCINOMA CELLS (T-56) |
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| Wang Yu-ming,Wang Yu-fen,Yang Fu-hua and Wang Yu-sheng. EFFECTS OF POLYACTIN A ON THE GROWTH OF THE HUMAN TONGUE SQUAMOUS CARCINOMA CELLS (T-56)[J]. Chinese Journal of Antibiotics, 1993, 18(1): 55-58 | |
| Authors: | Wang Yu-ming Wang Yu-fen Yang Fu-hua Wang Yu-sheng |
| Abstract: | The biological effect of PAA on the T-56 cells was investigated by the conventional methods of cell biology (incorporation of the radioisotopes; liquid scintillation counting; determining the growth curve; contrasting the cells life rate). It was found that PAA resulted in the inh-ibiton of cell proliferation; an increase in population doubling time;a reduction in growth proliferating multiple and saturation densities. These findings suggest that PAA has certain role in inducing cell differentiation and antitumor activity. The mechanism of action of PAA on T-56 cells may relate to inhibition of synthesis of RNA. The toxicity and side effect of PAA is very low. |
| Keywords: | Polyactin A T-56 Cell Incorporation of the radioisotope |
| 本文献已被 CNKI 维普 等数据库收录！ | |