糖化白蛋白与糖尿病肾功能的关系研究

目的：探讨血清糖基化白蛋白（GA）水平与2型糖尿病肾功能不全的关系及其检测意义。方法：选正常人群98例为正常对照纽（A纽）；另选2型糖尿病患者153例，根据其血清肌酐清除率（Ccr）分为4组：B组（12例）Ccr≤30mL·min^-1；C组（62例）30mL·min^-1〈Ccr≤60mL·min^-1；D组（61例）60rnL·min^-1〈Ccr≤90mL·min^-1；E组（18例），Ccr〉90mL·min^-1测各组血清GA水平及糖化血红蛋白水平（HbAlc）。结果：GA水平B组（19．32％±4．26％）、C组（17．03％±3．41％）、D组（16．37％±4．00％）、E组（16．87％±4．27oA）与A组的GA水平（14．98％±1．64％）均有显著性差异。C组、D组、E组的GA水平与B组的GA水平有显著性差异。HbA1c水平B组、C组及D组与A组有显著性差异，E组与A组差异无显著性。B组、C组、D组、E组之间的HbA1c均无显著性差异。结论：2型糖尿病患者合并严重肾功能不全时GA水平升高，它可能是2型糖尿病合并肾功能不全的危险因素。

Investigation of The Relationgship between Serum Glycated Albumin and Kidney Disfunction with Type 2 Diabetes Mellitus

Objective： to analyze the relationship between glycated albumin and renal function among diabetics, and find out the correlation between the both. Methods： We choose 98 normal persons as control group （group A）and 153 diabetics patients. According to the Ccr , the diabetics patients were divided into four groups, as group B （Ccr≤30 mL · min^-1 ,n = 12） , group C （30mL · min^-1Ccr≤60 mL · min^-1, n =62） , group D（60 mLmL · min^-1Ccr≤90 mL · min^-1, n =61）and groupE （Cer〉90 mL · min^-1, n = 18）. Results：statistical analysis results displayed the GA was significant difference among group A （14.98% ± 1.64%）,group B（19.32% ± 4.26%）,group C（17.03% ± 3.41 %） ,group D（16.37% ±4. 00V0）and group E（16. 87% ±4.27%） but the HbAlc was significant difference among group A, group B ,group C and group D,instead there was no difference with group E. Conclusion： HbA1c and GA are both indicators for blood glucose control in diabetics. Better than HbA1c , GA indicated the renal function degreely in diabetics.