奥扎格雷治疗急性脑梗死患者的疗效及其对血浆D-二聚体和血管性假血友病因子的影响

目的：观察奥扎格雷治疗急性脑梗死（ACI）患者的近期疗效及其对血浆D-二聚体（D-D）和血管性假血友病因子（vWF）的影响。方法：42例ACI患者给予脱水、降压等常规综合治疗,在此基础上给予奥扎格雷氯化钠注射液80mg.100mL-1,静脉滴注,bid,连续2周。观察疗效,治疗前、后神经功能缺损程度评分（NDS）和日常生活活动能力评分（ADL）改善情况及不良反应;测定血浆D-D、vWF含量,并与30名健康体检者比较（对照组）。结果：治疗后,患者NDS和ADL评分均显著改善,与治疗前比较,差异有统计学意义（P〈0.05或P〈0.01）,总有效率为90.5%。治疗前,ACI患者血浆D-D、vWF含量均显著高于对照组（P〈0.01）,治疗后ACI患者血浆D-D、vWF含量显著降低（P〈0.01）,但仍与对照组有显著性差异（P〈0.05）。结论：奥扎格雷能显著降低ACI患者血浆D-D、vWF水平,显著改善ACI患者NDS和ADL,且耐受性较好。

Therapeutic Efficacy of Ozagrel in the Treatment of Acute Cerebral Infarction and Its Effects on Plasma D-dimer and Von Wilebrand Factor

OBJECTIVE：To observe the short-term efficacy of ozagrel in the treatment of acute cerebral infarction（ACI） and its effect on plasma D-two dimers and von Willebrand factor（vWF）.METHODS：42 ACI patients were given routine treatment,including dehydration,hypotension.They were additionally given on Ozagrel sodium chloride injection 80 mg·100 mL-1,intravenous infusion,bid,for 2 consecutive weeks.Therapeutic efficacy,improvement of NDS score and ADL score and adverse drug reaction were observed before and after treatment.The contents of plasma D-D and vWF were determined,using 30 healthy physical examinees as control.RESULTS：After treatment,NDS score and ADL score were improved significantly than before,there was statistical significance（P0.05,P0.01）.Total effective rate was 90.5%.Before treatment,the contents of D-D and vWF in plasma in ACI patients were significantly higher than normal control group（P0.01）,and the contents of D-D and vWF in plasma were decreased significantly after treatment（P0.01）,but higher than control group（P0.05）.CONCLUSION：Ozagrel can significantly decrease D-D and vWF content in plasma of ACI patients,significantly improve NDS score and ADL score,and is well tolerated.