雾化吸入布地奈德混悬液与地塞米松治疗婴幼儿轻中度喘息性疾病的疗效比较

目的探讨雾化吸入布地奈德混悬液与地塞米松治疗婴幼儿轻中度喘息性疾病的临床疗效。方法选取我院呼吸病科收治的住院患儿128例,随机分为两组,每组64例。对照组在常规治疗的基础上给予地塞米松雾化吸入,观察组在常规治疗的基础上给予布地奈德混悬液雾化吸入,观察两组患儿的疗效及症状、体征改善情况。结果观察组患儿的显效率为84.38%、总有效率为98.44%显著高于对照组患儿的60.94%、89.06%(P<0.01,P<0.05);观察组患儿的喘息消失时间、咳嗽消失时间、喘鸣音消失时间及住院时间均明显短于对照组患儿(P<0.01)。结论雾化吸入布地奈德混悬液治疗婴幼儿轻中度喘息性疾病的临床疗效明显优于雾化吸入地塞米松,且安全性高,可有效改善临床症状,尽早恢复肺功能。

Efficacy comparison of atomization inhalation between budesonide suspension and dexamethasone in the treatment of infants with mild and moderate asthmatic disease

Objective To compare the efficacy of atomization inhalation between budesonide suspension and dexamethasone in the treatment of infants with mild and moderate asthmatic disease.Methods 128 infants with mild and moderate asthmatic disease were randomly and evenly divided into two groups.The control group was given dexamethasone atomization inhalation on the basis of conventional treatment,and the observation group was treated with the inhalation of budesonide suspension on the basis of conventional treatment.The efficacy and the improvement of clinical symptoms and physical signs were compared between the two groups.Results The effective rate was 84.38% and 60.94% and the total effective rate was 98.44% and 89.06% respectively in the observation group and in the control group（P0.01 or P0.05）.The cough disappeared time,wheezing disappeared time and hospital stay in the observation group were significantly shorter than that in the control group（P0.01）.Conclusion The atomization inhalation of budesonide has good clinical efficacy and high safety in the treatment of infants with mild and moderate asthmatic disease,which can effectively improve the clinical symptoms and restore lung function ASAP.