| 连续十年铜绿假单胞菌对碳青霉烯类抗生素耐药率分析 |
| |
| 引用本文： | 周秀珍,孙继梅,刘建华.连续十年铜绿假单胞菌对碳青霉烯类抗生素耐药率分析[J].中国全科医学,2010,13(13):1467-1469. |
| |
| 作者姓名： | 周秀珍 孙继梅 刘建华 |
| |
| 作者单位： | 中国医科大学附属盛京医院检验科,辽宁省沈阳市,110004 |
| |
| 摘 要： | 目的 探讨医院内铜绿假单胞菌(PAE)对碳青霉烯类抗生素的耐药率及其变迁情况,为临床治疗PAE感染提供参考依据.方法 用碳青霉烯类抗生素对1999-2008年临床分离的2 479株PAE进行药敏实验.结果 PAE感染以下呼吸道为主,主要分布在重症监护病房(24.6%)、神经外科(21.8%)等科室.耐药性、多重耐药性和泛耐药PAE的分离率逐年上升,其耐药率也逐年上升.PAE对亚胺培南和美罗培南的10年总平均耐药率分别为29.2%和25.7%.PAE 1999年对亚胺培南的耐药率为14.6%,2008年上升到53.8%,差异有统计学意义(P＜0.01);PAE 2000年对美罗培南的耐药率为0.2%,2008年上升到46.5%,差异有统计学意义(P＜0.01).结论 PAE对碳青霉烯类抗生素的耐药性呈明显上升趋势,临床应适当控制碳青霉烯类药物的使用,以有效控制及延缓耐药株的产生.
|
| 关 键 词： | 假单胞菌 铜绿 碳青霉烯类抗生素 耐药性 |
Resistance Change of Pseudomonas Aeruginosa to Carbapenems During Past Ten Years |
| |
| ZHOUXiu-zhen,SUNJi-mei,LIUJian-hua.ShengjingHospitalofChinaMedicalUniversity,Shenyang,China.Resistance Change of Pseudomonas Aeruginosa to Carbapenems During Past Ten Years[J].Chinese General Practice,2010,13(13):1467-1469. |
| |
| Authors: | ZHOUXiu-zhen SUNJi-mei LIUJian-huaShengjingHospitalofChinaMedicalUniversity Shenyang China |
| |
| Institution: | ZHOU+Xiu-zhen,SUN+Ji-mei,LIU+Jian-hua.Shengjing+Hospital+of+China+Medical+University,Shenyang+110004,China |
| |
| Abstract: | Objective To investigate the change of resistance of Pseudomonas aeruginosa(PAE)to Carbapenems in hospital so as to guide clinic treatment of PAE infection.Methods Drug sensitivity tests of 2 479 PAE strains clinically isolated during Jan 1999-Dec 2008 were made for Carbapenems.Results The common site infected by PAE was lower respiratory tract,and the main departments were ICU(24.6%)and neurosurgery(21.8%).The isolation rates of PAE with drug resistance,multi-drug resistance and panresistant strains increa... |
| |
| Keywords: | Pseudomonas aeruginosa Antimicrobial agent carbapenem Drug resistance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
