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| 黏着斑激酶在结直肠癌中的表达及临床意义 | |
| 引用本文： | 牛宏立,王万里. 黏着斑激酶在结直肠癌中的表达及临床意义[J]. 河南科技大学学报(医学版), 2008, 26(3) |
| 作者姓名： | 牛宏立 王万里 |
| 作者单位： | 洛阳东方医院,河南洛阳,471003;洛阳东方医院,河南洛阳,471003 |
| 摘 要： | 目的 研究结直肠癌相关黏着斑激酶(focal adhesion kinase,FAK)在不同结直肠黏膜中的表达及其与结直肠癌各种临床病理因素之间的关系.方法 标本来源于癌组织手术切除标本.免疫组织化学染色法检测FAK,比较分析FAK在不同结直肠癌组织中的表达.结果 随着结直肠癌浸润深度加深,FAK阳性率升高;淋巴结转移组阳性率高于非淋巴结转移组.结论 FAK表达可能参与结直肠癌的发生.并与结直肠癌浸润转移有密切关系. |
| 关 键 词： | 黏着斑激素 结直肠癌 免疫组化 |
Expression of FAK in Colorectal Cancer and Its Clinical Significance |
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| NIU Hong-li,WANG Wan-li. Expression of FAK in Colorectal Cancer and Its Clinical Significance[J]. Journal of Henan University of Science & Technology:Medical Science, 2008, 26(3) | |
| Authors: | NIU Hong-li WANG Wan-li |
| Affiliation: | NIU Hong-li,WANG Wan-li(Luoyang Dongfang Hospital,Luoyang 471003,China) |
| Abstract: | Objective To evaluate the expression of colorectal cancer related to focal adhesion kinase(FAK) in different colorectal mucosa and the relationship with the hispathology of colorectal cancer. Methods The samples were obtained from colorectal carcinoma resection specimens.The expression of FAK was assayed by immunohistochemical staining,compared with the expression of FAK in different colorectal carcinoma. Results The results showed the FAK positive rate was related to the staging of carcinoma.and was in acc... |
| Keywords: | focal adhesion kinase(FAK) colorectal cancer immunohistochemistry |
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