妊娠糖尿病患者血清同型半胱氨酸、胱抑素C与胰岛功能的关系

目的探讨妊娠糖尿病(GDM)患者血清同型半胱氨酸(Hcy)、胱抑素C(Cys C)水平的变化及其与胰岛功能的关系。方法选择2012年1月至2012年12月门诊确诊的240例GDM患者作为观察组,100例同期健康孕妇作为对照组。通过对血Hcy、Cys C、空腹血糖(FBG)、空腹胰岛素(FINS)的测定,比较两组患者血Hcy、Cys C、FBG、FINS、HOMA-IR、HOMA-β水平,并分析血Hcy、Cys C与HOMA-IR、HOMA-β的相关性。结果观察组Hcy、Cys C、FBG、FINS、HOMA-IR明显高于对照组,两组间HOMA-β无明显差别;Hcy、Cys C与HOMA-IR正相关,与HOMA-β无明显相关性。结论 GDM患者HOMA-IR、FINS、Hcy、Cys C明显升高,Hcy、Cys C与HOMA-IR正相关。提示GDM患者存在胰岛素抵抗,血Hcy、Cys C水平的测定可作为GDM患者的监测指标。

The Relationship Between Homocysteine and Cystatin C in the Serum of Gestational Diabetes Mellitus Patients and Islet Function

Objective To explore the changes of homocysteine（Hcy）and cystatin C（Cys C） level in the serum of gestational diabetes mellitus patients（GDM）, and the relationship between the changes and islet function. Methods Selecting 240 cases of GDM diagnosed from outpatient from January to December in 2012 as a observation group, and selecting 100 cases of healthy pregnant women over the same period as a control group. To determine Hcy, Cys C, fasting blood glucose（FBG）and fasting insulin（FINS）in the blood, and comparing the levels of Hcy, Cys C, FBG, FINS, HOMA-IR and HOMA-β in the blood between these two groups. Then analyzing the correlation between Hcy, Cys C and HOMA-IR, HOMA-β. Results The levels of Hcy, Cys C, FBG, FINS and HOMA-IR in the observation group are significantly higher than the ones in the control group. There are no significant differences of HOMA-β＇s level between the two groups. The levels of Hcyand Cys C are positively correlated with HOMA-IR＇s level, but there is no significant correlation with HOMA-β＇s level. Conclusions The levels of Hcy, Cys C, FINS and HOMA-IR of GDM patients were significantly increased, and the levels of Hcy and Cys C are positively correlated with HOMA-IR＇s level. To prompt the GDM patients have insulin resistance. To prompt the determination of the levels of Hcy and Cys C in the blood can be the monitoring indicators of GDM patients.