宫腔内人工授精治疗后生化妊娠或临床妊娠53周期的相关因素分析

目的探讨宫腔内人工授精（intrauterine insemination,IUI）治疗后生化妊娠与临床妊娠周期的精液及临床影响因素。方法选择2010年6月至2013月2月因不孕症于广东医学院附属医院生殖医学中心进行IUI治疗的370周期,其中随访妊娠结局为生化妊娠的15周期为观察组,临床妊娠的38周期为对照组。比较分析两组患者IUI术中丈夫精液优化后的数据及患者临床数据。结果两组精液优化后的各项常规参数、女方不孕年限、体质量指数、年龄以及IUI日子宫内膜厚度、不孕诊断、不孕原因以及IUI方案方面比较,差异均无统计学意义（P〉0.05）。IUI日子宫内膜的不同类型在生化与临床妊娠的结局中比较,差异有统计学意义（P〈0.05）。结论 IUI后生化妊娠的原因,可能与IUI日子宫内膜的容受性不良有关。

The analysis on related factors of 53 intrauterine insemination cycles terminated in biochemical pregnancy or clinical pregnancy

Objective To investigate the semen and clinical factors of Intrauterine insemination （ IUI ） cycles terminated in biochemical and clinical pregnancy. Methods Selected 370 IUI treatment cycles diagnosed infertility which were treated in Reproductive Medicine Center of The Affiliated Hospital of Guangdong Medical College from June 2010 to February 2013, Including 15 cycles of biochemical pregnancy for the observation group and 38 cycles of clinical pregnancy for the control group. The clinical data and data from optimized husband＇s sperm were compared and analyzed after the process of IUI surgery in the two groups. Results The differences of the general parameters including optimized sperm, female duration of infertility, body mass index, age, endometrial thickness in IUI Day, infertility diagnosis, causes and IUI programs between two groups were not statistically significant （ P 〉 0. 05 ）. The difference within different types of endometrial in biochemical and clinical pregnancy outcomes were statistically significant （ P 〈 0. 05 ）. Conclusion The cause of biochemical pregnancy after IUI may be associated with poor endometrial receptivity in IUI days.