| CXCL12-CXCR4在胰腺癌侵袭转移中的作用 |
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| 引用本文： | 赵宁. CXCL12-CXCR4在胰腺癌侵袭转移中的作用[J]. 国际肿瘤学杂志, 2010, 37(3). DOI: 10.3760/cma.j.issn.1673-422X.2010.03.019 |
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| 作者姓名： | 赵宁 |
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| 作者单位： | 上海交通大学附属第一人民医院普外科,200080 |
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| 摘 要： | 目前研究发现趋化因子及受体CXCL12-CXCR4生物轴在胰腺癌的侵袭转移中起重要作用.CXCL12-CXCR4可通过促进胰腺癌细胞增殖、增强癌细胞的迁移、促进细胞外基质蛋白降解和血管新生等机制而促进胰腺癌的侵袭转移.
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| 关 键 词： | 趋化因子类 受体 趋化因子 胰腺肿瘤 肿瘤浸润 肿瘤转移 |
Effects of CXCL12-CXCR4 in the invasion and metastasis of pancreatic cancer |
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| ZHAO Ning. Effects of CXCL12-CXCR4 in the invasion and metastasis of pancreatic cancer[J]. Journal of International Oncology, 2010, 37(3). DOI: 10.3760/cma.j.issn.1673-422X.2010.03.019 |
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| Authors: | ZHAO Ning |
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| Abstract: | Recent researches have revealed that the CXCL12/CXCR4 bio-axis is pivotal in the invasion and metastasis of pancreatic cancer. CXCL12/CXCR4 may promote the tumor invasion and metastasis through the mechanism of stimulating the proliferation of cancer cells, enhancing the migration of tumor cells, inducing the extra-cellular matrix degradation and angiogenesis. |
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| Keywords: | Chemotactic factors Receptors,chemokine Pancreatic neoplasms Neoplasm invasion Neoplasm metastasis |
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