西酞普兰合并阿立哌唑治疗老年抑郁症的对照研究

目的探讨西酞普兰合并阿立哌唑治疗老年抑郁症的疗效。方法将60例老年抑郁症患者随机分成西酞普兰组（单用组）和西酞普兰合并阿立哌唑组（合用组）。共观察6周。于治疗前、后1、2、4、6周末采用汉密尔顿抑郁量表（HAMD），不良反应量表（TESS）评定疗效及不良反应。结果治疗第6周末，西酞普兰合用阿立哌唑组疗效显著，合用组与单用组的有效率分别为83．3％和60％，有显著性差异（X^2=4．021，P〈0．05）；合用组在1周末起效，单用组在2周末起效；两组治疗后1、2、4周HAMD评分有显著性差异（P〈0．05）；TESS评分无明显差异（P〉0．05）。结论西酞普兰合并阿立哌唑治疗老年抑郁症起效快，克服了抗抑郁药起效慢的特点。

A clinical observation of effect of citalopram with aripiprazole in senile depression

Objective To study the clinical effect of citalopram with aripiprazole in the treatment of senile depression.Methods 60 hospitalized patients who met CCMD-3 criteria of senile depression were randomly divided into research (citalopram and aripiprazole) group and control (citalopram) group for the treatment of 6 weeks.The efficacy and side effects were evaluated with HAMD and TESS.Results The treatment of citalopram with aripiprazole was effective and the tolerance was better after 6-week treatment.There were significant differences in HAMD of first week,second week,forth week after treatment between two groups.But there was no difference in TESS.Conclusion Citalopram with aripiprazole could improve the efficacy compared with citalopram in treating senile depression.