| 腺苷酸活化蛋白激酶与胰岛素抵抗 |
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| 引用本文： | 胡淑国,宋光耀. 腺苷酸活化蛋白激酶与胰岛素抵抗[J]. 国外医学:内科学分册, 2009, 36(3): 137-140 |
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| 作者姓名： | 胡淑国 宋光耀 |
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| 作者单位： | 石家庄市第二医院内分泌科,河北,石家庄,050051;河北省人民医院,河北省老年医学重点实验室,河北,石家庄,050051 |
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| 摘 要： | 腺苷酸活化蛋白激酶（AMP-activated protein kinase, AMPK）是一类重要的蛋白激酶,通过改变细胞代谢和调节基因转录恢复细胞ATP水平。AMPK参与了肌肉收缩介导的葡萄糖转运和脂肪酸氧化,抑制肝脏葡萄糖、胆固醇和甘油三酯产生,并具有调节食物摄取和体重的作用。AMPK信号通路是目前具有吸引力的治疗肥胖、胰岛素抵抗、2型糖尿病和其它代谢病的药理靶点。
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| 关 键 词： | 腺苷酸活化蛋白激酶 葡萄糖转运 脂肪酸氧化 胰岛素抵抗 |
AMP-activated protein kinase and insulin resistance |
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| HU Shu-guo,SONG Guang-yao. AMP-activated protein kinase and insulin resistance[J]. Foreign Medical Sciences(Section of Internal Medicine), 2009, 36(3): 137-140 |
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| Authors: | HU Shu-guo SONG Guang-yao |
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| Affiliation: | HU Shu-guo1,SONG Guang-yao2.1 Department of Endocrinology,The Second Hospital of Shijiazhuang City,2 Institute of Geriatric Medicine,General Hospital of Hebei Province,Shijiazhuang 050051,China |
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| Abstract: | AMP-activated protein kinase (AMPK) is a vital protein kinase that has the function of restoring cellular ATP levels by modifying diverse metabolic pathways and regulating gene transcription. In the skeletal muscle, AMPK is involved in contraction-stimulated glucose transport and fatty acid oxidation. In the liver, AMPK inhibits the production of glucose, cholesterol and triglycerides. AMPK also plays a major role in the regulation of food intake and body weight. AMPK signaling pathway may be an attractive ... |
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| Keywords: | AMP-activated protein kinase Glucose transportation Fatty acid oxidation Insulin resistance |
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