| 外用制剂朱红膏肾脏早期毒性敏感指标NAG、RBP的监测 |
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| 引用本文： | 王乐平,董建勋,罗玲,李建荣,贺蓉,彭博,徐启华,林含,张旭辉.外用制剂朱红膏肾脏早期毒性敏感指标NAG、RBP的监测[J].中华中医药杂志,2011(10):2261-2264. |
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| 作者姓名： | 王乐平 董建勋 罗玲 李建荣 贺蓉 彭博 徐启华 林含 张旭辉 |
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| 作者单位： | 北京中医药大学;首都医科大学附属北京中医医院;中国中医科学院中药研究所; |
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| 基金项目： | 国家科技支撑计划课题(No.2008BAI53B085)~~ |
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| 摘 要： | 目的:筛选朱红膏肾脏靶器官早期毒性的敏感指标。方法:将80只SD大鼠随机分为8个组:朱红膏A、B、C、D、E,5个剂量组,基质组(凡士林),溃疡模型组及皮肤破损组。连续给药14d,记录给药7d及14d大鼠体质量,并测定尿液pH值及NAG、RBP水平。结果:A、B、C、D组大鼠体质量增长受到抑制;给药7d,尿液存在大量酸性样本,不符合检测β2-MG的条件;给药7d,A组NAG及RBP水平均升高;给药14d,A组NAG水平升高,A、B、C、D组RBP含量均明显升高。结论:RBP可以作为朱红膏肾脏靶器官早期毒性的监测指标,并且较NAG敏感。
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| 关 键 词： | 朱红膏 皮肤溃疡 肾 β-N-乙酰氨荃葡萄糖苷酶 视黄醇结合蛋白 |
Detecting the sensitive indicators NAG and RBP of toxicity for early kidney tubular injury caused by Zhuhong Ointment |
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| WANG Le-ping,DONG Jian-xun,LUO Ling,LI Jian-rong,HE Rong,PENG Bo,XU Qi-hua,LIN Han,ZHANG Xu-hui.Detecting the sensitive indicators NAG and RBP of toxicity for early kidney tubular injury caused by Zhuhong Ointment[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(10):2261-2264. |
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| Authors: | WANG Le-ping DONG Jian-xun LUO Ling LI Jian-rong HE Rong PENG Bo XU Qi-hua LIN Han ZHANG Xu-hui |
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| Institution: | WANG Le-ping1,DONG Jian-xun2,LUO Ling1,LI Jian-rong3,HE Rong3,PENG Bo3,XU Qi-hua3,LIN Han2,ZHANG Xu-hui1(1Beijing University of Chinese Medicine,Beijing 100029,China,2Beijing Hospital of Chinese Medicine,Capital Medical University,Beijing 100010,3Institute of Chinese Materia Medica,China Academy of Chinese Medical Science,Beijing 100700,China) |
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| Abstract: | Objective: To select the sensitive indicators of toxicity for early kidney tubular injury caused by Zhuhong Ointment.Methods: SD rats(n=80) were randomly divided into different dose groups,A,B,C,D and E,Vaseline group,ulcer model group and impairment control group.Spread Zhuhong Ointment on ulcers,which were established on the absence skin,foreign body and staphylococcal infection,every day for 2 weeks.Body weight was recorded once every week.Tested urine pH and compared NAG with RBP after administration fo... |
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| Keywords: | Zhuhong Ointment Skin ulcers Kidney NAG RBP |
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