64排螺旋CT灌注诊断涎腺肿瘤的临床应用研究

目的:评价64排螺旋CT灌注成像对涎腺肿瘤的临床诊断价值。方法:29例涎腺部肿瘤(腮腺22例,颌下腺6例,舌下腺1例;其中良性肿瘤17例,恶性肿瘤12例)行CT灌注检查,取得相应的灌注参数:血流量(blood flow,BF),血容量(blood volume,BV),平均通过时间(mean transit time,MTT)和表面渗透性(permeability surface,PS),并均经术后病理证实。结果:所有肿瘤的BF、BV、MTT和PS值明显高于正常涎腺组织(P<0.05),恶性肿瘤组BF、BV、PS值高于良性肿瘤组(P<0.05),MTT参数则在良、恶性肿瘤之间无统计学差异。结论:涎腺肿瘤的CT灌注成像是一种较为准确的定量分析肿瘤血流灌注状态的方法,具有较高的临床应用价值。

A clinical study of perfusion imaging using 64-slice SCT in the diagnosis of salivary gland tumor

Objective:To assess clinical utility of perfusion imaging using 64-slice SCT(spiral CT) in the diagnosis of salivary gland tumor.Methods: Perfusion CT was performed with 64-slice SCT in 29 patients of salivary gland tumor (22 cases in parotid gland, 6 cases in submandibular gland and 1 case in sublingual gland;17 benign and 12 malignant)and perfusion parameter,including blood flow(BF),blood volume (BV),mean transmit time (MTT),and permeability-surface area (PS) were analyzed.The surgical and pathological outcomes were collected for comparison. Results:All the values of BF,BV MTT and PS of the tumors were obviously higher than those of the normal salivary gland tissues(P<0.05)and the values of BF,BV and PS of the malignant tumors were higher than those of benign tumors significantly. However, the MTT values showed no significant difference between benign and malignant tumors(P>0.05). Conclusions:CT perfusion imaging is an accurate means for analyzing blood perfusion state, which may play an important role in the diagnosis of salivary tumors.