经皮冠状动脉介入治疗急性心肌梗死过程中超敏C-反应蛋白的动态观察

目的观察经皮冠脉介入治疗急性心肌梗死（AMI）患者血清高敏C-反应蛋白（hs—CRP）的动态变化规律。方法选择60例确诊急性心肌梗死患者于发病6h内行急诊经皮冠脉介入治疗为介入组，用免疫比浊法分别测定所有患者冠状动脉介入治疗（PCI）术前、即刻、术后6、12、24、72h及7d hs-CRP水平，同时30例健康体检者为正常对照，并进行统计学分析。结果PCI组介入治疗后AMI患者血浆hs-CRP水平随时间逐渐升高，在术后72h上升至高峰值，并于7d后恢复至术后12h水平，术后6、12、24、72h及7dhs—CRP水平显著高于正常对照组（P〈0．05），术后72h高峰值与其他时间点比较均有显著性差异（P〈0．05）。结论经皮冠脉治疗急性心肌梗死患者，发病后短期hs—CRP水平随时间呈动态变化，可作为PCI治疗AMI疗效观察指标之一。

Dynamic Observation on High-sensitivity C-reactive Protein in Acute Myocardial Infarction After Percutaneous Coronary Intervention

Objective To observe the dynamic change of high-sensitivity C-reactive protein(hs-CRP)after percutaneous coronary intervention (PCI)within 6 hours after attack of acute myocardial infarction(AMI).Methods The hs-CRP levels in serum was detected in 60 AMI patients within 6 hours after attack with immunoturbidimetry before PCI, at the opint of operation ,6 h, 12 h ,24 h ,72 h .and 7 d after PCI. 30 healthy examinationer were chosen as normal control. The two groups were compared with statistics. Results The hs-CRP levels were increased gradually with time in AMI patients after PCI. The peak value was at 72 h after PCI and recovered to the level of 12 h after PCI at 7 d after PCI. The hs-CRP levels at 6 h,12 h,24 h,72 h and 7 d were significantly higher than those in the normal group (P ＜ 0. 05) , and hs-CRP at 72 h were significant higher than those at other opints(P ＜ 0. 05). Conclusion The hs-CRP levels in short time after attack of AMI with PCI presented an dynamic changing and it can be one of the indexes on curative effect on AMI with PCI.