羟基喜树碱联合氟尿嘧啶顺铂治疗晚期食管癌

目的观察HCPT＋DDP＋5-Fu方案治疗晚期食管癌的疗效。方法本组晚期食管癌46例。HCPT8～10mg／m^2，第1～5d，DDP60～80mg／m^2，第1d,5-Fu0．75g／m^2，第1～5d；21d或28d为一周期，每例病人至少完成3周期。结果46例中无一例CR，21例PR，12例NC，13例PD。有效45．7％。结论HCPT＋DDP＋5-Fu方案治疗晚期食管癌有效，不良反应能耐受。

Observation of Hydroxycamptothecin Combined with 5 -fluorouracil and Cisplatin in Treatment of Advanced Esophageal Cancer

Objective To evaluate the result of combination of HCPT,5-Fu and DDP in treatment of advanced esophageal cancer.Methods 46 patients with advanced esophageal cancer were entrolled in this study.HCPT 8~10mg/m~2 from the 1~(st) to 5~(th) day,DDP 60~80mg/m~2 in the 1~(st) day,and 5-Fu 0.75g/m~2 from the 1~(st) to 5~(th) day were given venous instillation.Every 21 days or 28 days is one cycle.Every patient was given three cycles at least.Results There were O CR,21 PR,12 NC,13 PD in the 46 patients.The response rate(CR PR) was 45.7%.Conclusion Treatment on advanced esophageal cancer with HCPT,DDP and 5-Fu is efficient and the toxicity is tolerable.