| GABAA受体部分介导脊髓水平5—HT的镇痛作用 |
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| 引用本文： | 杨俊曾,王瑞.GABAA受体部分介导脊髓水平5—HT的镇痛作用[J].长治医学院学报,1995,9(3):194-196. |
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| 作者姓名： | 杨俊曾 王瑞 |
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| 作者单位： | 山东省利津县第一人民医院，山西医学院，北京医学高等专科学校 |
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| 摘 要： | 本工作利用大鼠辐射热－甩尾测痛结合脊髓蛛网膜下腔注药的方法，观察了ｒ－氨基丁酸Ａ（ＧＡＢＡＡ）受体阻断剂荷包牡丹碱对５－羟色胺镇痛作用的影响。实验结果如下：（１）脊髓蛛网膜下腔０．５ｎｍｏｌ ＢＩＣ能够对注射１２０ｎｍｏｌ５－ＨＴ所引起的镇痛作用产生较迟的部分阻断作用，但这一剂量的ＢＩＣ却能完全阻断注射１ｎｍｏｌＧＡＢＡＡ受体激动剂ｍｕｓｃｉｍｏｌ所的明显强于１２０ｎｍｏｌ５－ＨＴ的镇痛作用；（２
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| 关 键 词： | γ－氨基丁酸 GABAA受体 镇痛 血清素 药理学 |
The Partial involvement of GABAA-Receptors inSerotonin-Induced Analgesia at the Spinal Level |
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| Yang junzeng,et alNo.The Partial involvement of GABAA-Receptors inSerotonin-Induced Analgesia at the Spinal Level[J].Journal of Changzhi Medical College,1995,9(3):194-196. |
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| Authors: | Yang junzeng No |
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| Institution: | Yang junzeng,et alNo. 1 the people hospital of Lijin in Shandong |
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| Abstract: | The effects of intrathecally administered (i, t. ) GABAA-raceptor antaganist bicuculline (BIC) on the analgesia produced by i. t. serotonin (5-HT) or muscimol (MUS,a selective GABAA-receptor aganist) were observed and compared in rats using tail-flick (TF) test.The results show that: 1) i. t. BIC (0. 5nmol) can produce a partial and later blockade to theallalgesia produced by 5-HT (120nmol), but shows a complete blockade to that produced byMUS (1nmol); while the analgesic effect of MUS at this dosage is much stronger than that of 5-HT: 2) BIC alone exhibits on efiects on the tail-flick latency. The results suggest thatGABAA-receptors may partially mediate the 5-HT-induced analgesia at the spinal level. |
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| Keywords: | : GABAA-receptor Serotonin Bicucul line Muscimol Analgesia |
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