Reversible oligohydramnios in the second trimester of pregnancy in two patients with long-term diclofenac exposure |
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| Institution: | 1. Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy, Charité—Universitätsmedizin Berlin, Germany;2. Department of Obstetrics and Gynecology, University of Rostock, Rostock, Germany;3. Obstetrics and Gynecology, Center for Prenatal Diagnosis Kudamm-199, Berlin, Germany;1. Department of Pediatrics CHU (University Hospital) and CIC 1414, Rennes, France;2. Department of Pharmacy, CHU Rennes, France;3. Department of Obstetrics, Clinique La Sagesse, Rennes, France;4. Department of Obstetrics and Prenatal Diagnosis, CHU Rennes, France;1. Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, United States;2. Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY, United States;3. Birth Defects Center, University of Louisville, Louisville, KY, United States;1. Department of Pediatric Allergy and Immunology, Ankara Children''s Hematology Oncology Training and Research Hospital, Ankara, Turkey;2. Department of Pediatric Allergy and Immunology, Ankara Children''s Hematology Oncology Training and Research Hospital, Ankara, Turkey;3. Department of Pediatric Rheumatology, Ankara Children''s Hematology Oncology Training and Research Hospital, Ankara, Turkey;4. Department of Pediatric Allergy and Immunology, Mu?la S?tk? Kocman University, Mugla, Turkey;1. School of Biological Sciences, University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong SAR, PR China;2. Department of Life Sciences, College of Science and General Studies, Alfaisal University, Al Maather, P.O. Box 50927, Riyadh 11533, Kingdom of Saudi Arabia |
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| Abstract: | The use of non-steroidal anti-inflammatory drugs like diclofenac in the third trimester of pregnancy can cause severe side effects, in particular oligohydramnios, premature closure of ductus arteriosus, and fetal kidney damage. However, the treatment with non-steroidal anti-inflammatory drugs until gestational week 28 is accepted as relatively safe. Here we describe two retrospectively reported cases of early-onset oligohydramnios associated with long-term diclofenac exposure of at least 150 mg per day. The pathological findings were detected at gestational weeks 22 and 23, respectively. Amniotic fluid turned to normal after discontinuation of diclofenac in both cases, suggesting causality. Although early-onset oligohydramnios is a rare complication, caution for long-term diclofenac use in high doses is recommended even before gestational week 28. |
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| Keywords: | Adverse drug effects Diclofenac NSAID Oligohydramnios Pregnancy |
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