首页 | 本学科首页   官方微博 | 高级检索  
     


The Role of Hypofractionated Radiotherapy in Prostate Cancer
Authors:Linus C. Benjamin  Alison C. Tree  David P. Dearnaley
Affiliation:1.Division of Radiotherapy and Imaging,The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust,London,UK;2.Royal Marsden NHS Foundation Trust and the Institute of Cancer Research,London,UK
Abstract:

Purpose of Review

It is now accepted that prostate cancer has a low alpha/beta ratio, establishing a strong basis for hypofractionation of prostate radiotherapy. This review focuses on the rationale for hypofractionation and presents the evidence base for establishing moderate hypofractionation for localised disease as the new standard of care. The emerging evidence for extreme hypofractionation in managing localized and oligometastatic prostate cancer is reviewed.

Recent Findings

The 5-year efficacy and toxicity outcomes from four phase III studies have been published within the last 12 months. These studies randomizing over 6000 patients to conventional fractionation (1.8–2.0 Gy per fraction) or moderate hypofractionation (3.0–3.4 Gy per fraction). They demonstrate hypofractionation to be non-inferior to conventional fractionation.

Summary

Moderate hypofractionation for localized prostate cancer is safe and effective. There is a growing body of evidence in support of extreme hypofractionation for localized prostate cancer. Extreme hypofractionation may have a role in managing prostate oligometastases, but further studies are needed.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号