胰岛素中空栓剂的制备及兔体药效实验

 目的研究胰岛素中空栓剂的制备及对正常家兔的降糖效果。方法用普通栓剂模具制备,以半合成脂肪酸酯为基质,以甘油为溶剂,月桂氮-酮为吸收促进剂,每枚栓剂含胰岛素4u,对其融变时限、含量等进行测定;将中空栓剂置于家兔直肠内,用酶-苯酚法测定家兔血糖,并与皮下注射进行比较。结果融变时限符合药典要求,含量为4u,胰岛素中空栓剂的降糖效果与皮下注射胰岛素1u相当。结论胰岛素中空栓剂有较好的吸收,可能成为胰岛素非注射给药的有效载体。

Studies on insulin hollow suppositories:preparation and pharmacodynamics in rabbits

OBJECTIVE The study was undertaken to prepare the hollow suppository of insulin and to investigate the hypoglycemic effect in rabbits.METHODS Using ordinary suppository tools ,semi-synthesized fatty acid grease as base,glycerin as solvent,laurocapmap as absorption enhancer,every suppository contained 4 u insulin.Melt time limit and content was measured.The insulin hollow suppositories were placed into rectums of rabbits,and hypoglycemic effect was investigated.RESULTS The melt time limit coincided with the Chinese Pharmacopeia.The hypoglycemic effect was correspondent with insulin 1.0 u subcutaneous injection.CONCLUSION The insulin hollow suppository can be absorbed well,and may be a new drug carrier.