激素替代治疗对绝经后妇女乳腺的影响

目的:探讨激素替代治疗对绝经后妇女乳腺的影响.方法:选择有子宫的、绝经1年以上的绝经后妇女120例随机分为两组,A组56例使用尼尔雌醇加安宫黄体酮;B组64例使用利维爱,连续使用1年,观察乳房胀痛发生率、X线钼靶乳腺密度改变情况,并选择同期未用性激素替代治疗的绝经后妇女50例为C组.结果:A组乳房胀痛的发生率76.8%显著高于B组的18.8%和对照组的8%,P均＜0.05.A组的乳腺密度32.1%显著高于B组的9.4%和对照组的6.0%,P均＜0.05;但B组与C组无显著性差异,P＞0.05.结论:激素替代治疗中使用利维爱乳房胀痛发生率较低,对乳腺密度影响小,是一种相对安全的治疗方法.

Effect of Hormone Replacement Therapy on Mammograph Density in Postmenopausal Women

Objective: To evaluate the effect of different hormone replacement therapy (HRT) regimens on mammographic density in postmenopausal women. Methods: 120 postmenopausal women were divided into two groups: group A(n=56) were given nilestriol and plused medroxyprogesterone (MPA); group B(n=64) were given Tibolone and group C(n=50) were postmenopausal women who had not use hormone. Mammography was taken and analyzed by independent ratio-logist blinded to postmenopausal women after administration. Results: The rate of mammary pain in group A (76.8%) was significantly higher than that of group B (18.8%) and the control group (8%). The mammographic density increased 32.1% in group A and 9.4% in group B. The mammographic density significantly increased in group A(P < 0.05) and did not significantly increase in group B compared with control group(P > 0.05); the mammographic density in group A significantly increased compared with group B(P < 0.05). Conclusion: There is a low incidence rate with mammary pain and a low influence in breast density in the women treated with Tibolone.