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Enhancement of diagnostic efficiency by a gamma interferon release assay for pulmonary tuberculosis |
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| Authors: | Kanunfre Kelly Aparecida Leite Olavo Henrique Munhoz Lopes Max Igor Litvoc Marcelo Ferreira Antonio Walter |
| Affiliation: | Laboratory of Seroepidemiology and Immunobiology, Instituto de Medicina Tropical de São Paulo, University of São Paulo, São Paulo, Brazil,1. Clinic for Infectious Diseases of the Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil,2. Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, Brazil3. |
| Abstract: | This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to >or=0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test. |
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