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| 绵马贯众中绵马贯众素大孔树脂纯化工艺研究 | |
| 引用本文： | 王海宁,谢印芝,樊飞跃,刘培勋,龙伟. 绵马贯众中绵马贯众素大孔树脂纯化工艺研究[J]. 中国药师, 2008, 11(7): 765-768 |
| 作者姓名： | 王海宁 谢印芝 樊飞跃 刘培勋 龙伟 |
| 作者单位： | 1. 中国医学科学院放射医学研究所,天津,300192 2. 天津美伦医药集团 |
| 摘 要： | 目的：考察大孔吸附树脂对绵马贯众中绵马贯众素的吸附分离性能。方法：采用HPLC测定绵马贯众素含量，静态吸附分离法确定适合的大孔吸附树脂，动态吸附分离法确定分离条件。结果：DM130大孔吸附树脂对绵马贯众素有良好的吸附分离性能，其分离工艺条件为：绵马贯众素上样质量浓度为0．683mg·ml^-1，最大上样量为6．147mg·ml^-1树脂，5BV水及30％乙醇先后洗去杂质，5BV95％乙醇洗脱。结论：DM130树脂交换吸附绵马贯众中绵马贯众素的纯化方法可取，具有良好的应用前景。 |
| 关 键 词： | 绵马贯众 绵马贯众素 大孔吸附树脂 分离纯化 绵马贯众素 大孔树脂 纯化方法 工艺研究 Resins Adsorption Dryopteris Rhizoma Separation and Purification 前景 应用 交换吸附 醇洗 去杂质 乙醇 上样量 质量浓度 工艺条件 分离条件 结果 |
Technology of Separation and Purification of Dryocrassine in Rhizoma Dryopteris Crassirhizomatis by Macroporous Adsorption Resins |
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| Wang Haining,Xie Yinzhi,Fan Feiyue,Liu Peixun,Long Wei. Technology of Separation and Purification of Dryocrassine in Rhizoma Dryopteris Crassirhizomatis by Macroporous Adsorption Resins[J]. China Pharmacist, 2008, 11(7): 765-768 | |
| Authors: | Wang Haining Xie Yinzhi Fan Feiyue Liu Peixun Long Wei |
| Affiliation: | Wang Haining~1 Xie Yinzhi~2 Fan Feiyue~1 Liu Peixun~1 Long Wei~1 (1.Institute of Rediomedical,Chinese Academy of Medical Seiences,Tianjin 300192,China,2.Meilun pharmaceutic group,Tianjin) |
| Abstract: | Objective:To set up the technology for adsorbing and separating Dryocrassine from Rhizoma Dryopteris Crassirhizomatis with macroperous adsorption resins.Method:The content of dryocrassine was determined by HPLC;the static adsorption and separation were used in investigating the macroporous adsorption resin;the dynamic adsorption and separation were used in studying the condition of adsorption and separation.Result:DM130 macroporous adsorption resin was more suitable in the following technological condition:... |
| Keywords: | Rhizoma Dryopteris Crassirhizomatis Dryocrassine Macroporous adsorption resin Separation and purification |
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