荆花胃康胶丸与法莫替丁片治疗十二指肠溃疡的对照研究

目的 比较荆花胃康胶丸与法莫替丁片治疗十二指肠溃疡的疗效与安全性。方法 200例十二指肠溃疡患者随机分为荆花胃康胶丸治疗组（100例）和法莫替丁对照组（100例），荆花胃康胶丸160mg，每日3次；法莫替丁片20mg，每日2次，均饭前口服，疗程均为4周。观察两组治疗前后症状、胃镜及幽门螺杆菌（helicobacter pylori，Hp）感染的变化及不良反应。结果 治疗组总体症状缓解、溃疡愈合疗效与对照组相当（均P〉0．05）；两组对胃脘病、返酸及上腹胀症状改善均有显著疗效（均P〈0．05）；治疗组对纳差、嗳气疗效显著优于对照组（均P〈0．05）。治疗组Hp根除率显著高于对照组（P〈0．05），不良反应发生率则低于对照组（P〈0．05）。结论 荆花胃康胶丸治疗十二指肠溃疡特别是在症状改善及Hp根除方面是一个值得推广的安全药物。

Comparative Study on Jinghua Weikang Capsule and Famotidine in Treating Duodenal Ulcer

ObjectiveTo compare the effect and security of Jinghua Weikang Capsule (JWC) and famotidine in treating duodenal ulcer. MethodsTwo hundred patients with duodenal ulcer were randomly divided into the treated group treated with JWC, 160 mg 3 times per day and the control group treated with famotidine 20 mg twice per day, both by orally taking before meal for 4 weeks, 100 cases in each group. Changes of symptom score, adverse reaction, helicobacter pylori (Hp) infection and endoscopic figure before and after treatment were observed. Results The general remission rate and the ulcer healing rate in the treated group were equal to those in the control group respectively (both P>0.05). Symptoms including belly ache, sour regurgitation and abdominal distension were ameliorated after therapy in both groups (all P<0.05). The effect in relieving anorexia and eructation and Hp eradication rate were significantly higher in the treated group than those in the control group (all P<0.05), while the incidence rate of adverse reaction in the treated group was remarkably lower than that in the control group (P<0.05). ConclusionJWC is an effective and safe remedy in treating duodenal ulcer, especially for symptom amelioration and Hp eradication, so it is worthy of expanding clinically.