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Prolactin response to single and multiple doses of haloperidol in schizophrenic patients |
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| Authors: | G.K. Ravichandran Ru-Band Lu Alla Shvartsburd Chandra H. Misra Beng T. Ho Myrna Kahn Robert C. Smith |
| Affiliation: | 1. G.K. Ravichandran, M.D., Ru-Band Lu, M.D., Alla Shvartsburd, M.S., Chandra H. Misra, Ph.D., and Robert C. Smith, M.D., Ph.D., are in the Section of Biological Psychiatry, and Beng T. Ho, Ph.D., and Myrna Kahn, M.S., are in the Section of Neurochemistry and Neuropharmacology, Texas Research Institute of Mental Sciences, Houston, TX, USA;2. Drs. Misra and Smith are also in the Department of Psychiatry and Pharmacology, Baylor College of Medicine, USA;3. Dr. Lu is now with Tri-Service General Hospital, Taipei, Taiwan, R.O.C. |
| Abstract: | Serum prolactin and blood levels of haloperidol were assessed in schizophrenic patients after single acute oral doses of haloperidol and during fixed dose treatment with this medication. Although significant intrapatient correlations between prolactin responses to different doses of haloperidol were found, no statistically significant interpatient relationship between haloperidol dose and prolactin response emerged. There were statistically significant relationships between steady-state plasma and red cell haloperidol levels (measured by radio- receptor or gas liquid chromatographic techniques) and serum prolactin response, but not between blood levels after the acute haloperidol dose and prolactin response. |
| Keywords: | Prolactin haloperidol schizophrenia |
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