国产丙硫咪唑治疗实验性包虫病与17例肝包虫病的初步观察

对实验感染的泡球蚴病小鼠,以丙硫咪唑50mg/k/d给药30～70天。治后虫囊重量较对照组降低75.7～78.9％。实验感染的细粒棘球蚴病小鼠给予相同剂量40～50天,囊重降低48.8～55.4％。从组织学与超微结构观察到囊壁发生退化变性,但虫囊再移植后均生长良好。 13例肝CE与4例肝AE患者,给服丙硫咪唑18mg/k/d。连服30天一疗程,间隔15天后重复给药3～13(平均5.6)疗程。治后6～13个月复查。CE病人中2例治愈,9例获部分有效或改善,2例失败。AE病人中,2例部分有效,2例改善。本文证实该药治疗包虫病有一定效果。

PRIMARV OBSERVATION IN THE THERAPY OF EXPERIMENTAL MICE AND HUMAN HYDATIDOSIS WITH ALBENDAZOLE

Being experimentally infected either with gravid segments of Echinococcus multilocularis or with its larvae transplanted intra-peritoneally, mice with alveolar echinococcosis (AE) were treated with albendazole in a dose of 50mg/ kg/d for 30-70 days.The weight of cysts decreased by 75.7-78.9%after treatment.While the Weight of cysts in mice with cystic echinococcosis (CE) infected by intraperitoneal infection of protoscolex of hydatid cyst from sheep only dropped 48.8-55.4% after receiving the same dose for 45-50 days. Afterbeing re-transplanted into mice, the cysts developed well though histologicaland, ultrastructural regression evidently occured.17 human cases, ot which 13 liver CE and 4 with liver AE (diagnosed by IHA, ELISA and B ultrasound),were given 18mg/kg of albendazole daily for 30 days.Half a month later, they were retreated 3-13 (average 5.6) courses. All the cases were reexamined 6-13 months after treatment. The results showed that 2 out of 13 CE cases were cured, 9 were partly effctive or improved, and the other 2 ineffective. While 2 out of 4 AE cases were partly effctive and the other 2 improved.During the treatment, two inoperable patients with liver and abdominal CE complicated with hematuria and lumbodynia, one of them died, and another two underwent hematemesis temporarily.The au.thors suggested that aJbendazole is effective on, hydatidosis, but not satisfactory yet.