Epileptiform activity in traumatic brain injury predicts post‐traumatic epilepsy |
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| Authors: | Jennifer A Kim MD PhD Emily J Boyle BS Alexander C Wu MPH Andrew J Cole MD Kevin J Staley MD PhD Sahar Zafar MD Sydney S Cash MD PhD M Brandon Westover MD PhD |
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| Institution: | 1. Department of Neurology, Massachusetts General Hospital, Boston, MA;2. Department of Emergency Neurology and Neurocritical Care, Massachusetts General Hospital, Boston, MA;3. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA |
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| Abstract: | We hypothesize that epileptiform abnormalities (EAs) in the electroencephalogram (EEG) during the acute period following traumatic brain injury (TBI) independently predict first‐year post‐traumatic epilepsy (PTE1). We analyze PTE1 risk factors in two cohorts matched for TBI severity and age (n = 50). EAs independently predict risk for PTE1 (odds ratio OR], 3.16 0.99, 11.68]); subdural hematoma is another independent risk factor (OR, 4.13 1.18, 39.33]). Differences in EA rates are apparent within 5 days following TBI. Our results suggest that increased EA prevalence identifies patients at increased risk for PTE1, and that EAs acutely post‐TBI can identify patients most likely to benefit from antiepileptogenesis drug trials. Ann Neurol 2018;83:858–862 |
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