早期宫颈癌病人的围术期症状研究

目的:评估早期宫颈癌病人的围术期症状和症状困扰。方法:选择2019年7月—2019年11月在成都市某三级甲等肿瘤专科医院住院的宫颈癌病人为研究对象。在术前、术后第1天、第2天、第3天、第5天、第7天、第14天、第21天发放并当场收回安德森症状系列量表妇科恶性肿瘤围术期模块中文版问卷。采用单因素重复测量方差分析、Bonferroni post hoc test方法、Pearson相关系数进行统计分析。结果:核心症状中,术前睡眠不安得分最高;术后第1天~第21天疲劳得分最高;疲劳、疼痛得分分别在术后第14天、第21天恢复至术前水平(P<0.05)。妇科恶性肿瘤症状中,术前头晕得分最高;术后第1天昏昏沉沉得分最高,术后第2天~第14天腹胀得分最高;腹胀得分在术后第21天恢复至术前水平(P<0.05)。围术期中工作困扰得分最高,其次是一般活动、走路(P<0.05)。结论:早期宫颈癌病人术后核心症状中疲劳最严重,疼痛持续时间最长;妇科恶性肿瘤症状中,术后2周内腹胀最严重,且持续时间最长;围术期中工作困扰水平最高。

Perioperative symptoms of patients with early-stage cervical cancer

Objective:To evaluate perioperative symptoms and related interference in patients with early-stage cervical cancer.Methods:From July 2019 to November 2019,cervical cancer patients who were hospitalized in the gynecological oncology department of Sichuan Cancer Hospital&Institute were selected as the study subjects.Before and on the 1st,2nd,3rd,5th,7th,14th and 21st days after surgery,the Chinese version of MD Anderson Symptom Inventory for measuring perioperative symptom burden in patients with gynecologic cancer(MDASI-PeriOp-GYN-C)was distributed and collected.Repeated measurement one-way ANOVA,Bonferroni post hoc test and Pearson correlation coefficient were used for statistical analysis.Results:Before and after surgery,disturbed sleep and fatigue was rated the most severe core item,respectively.The score of fatigue and pain recovered on the 14th and 21st days after surgery respectively(P<0.05).Dizziness was rated the most severe PeriOp-GYN item before surgery.After surgery,grogginess and bloating were the most severe PeriOp-GYN items on the 1st day and within 2 weeks,respectively.The score of bloating returned to the preoperative level on the 21th day after surgery(P<0.05).The highest level of interference was reported for work,followed by general activity and walking(P<0.05).Conclusions:For patients with early-stage cervical cancer after surgery,fatigue was the most serious and pain lasted the longest in the core symptoms.Among the PeriOp-GYN items,bloating was the most serious and lasted the longest within 2 weeks after surgery.Work interference was the highest grade.