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| BMP2在原发性肝癌患者血清中的表达 | |
| 引用本文： | 温彪,米俊杰,侯桃华,郭晓红,白春爱,许翠萍. BMP2在原发性肝癌患者血清中的表达[J]. 世界华人消化杂志, 2010, 18(4) |
| 作者姓名： | 温彪 米俊杰 侯桃华 郭晓红 白春爱 许翠萍 |
| 作者单位： | 山西医科大学,山西省太原市,030001;山西医科大学第一医院科研实验中心,山西省太原市,030001;山西医科大学第一医院科技处,山西省太原市,030001;山西医科大学第一医院消化内科,山西省太原市,030001 |
| 基金项目： | 山西省归国留学人员基金资助项目 |
| 摘 要： | 目的:探讨血清骨形态发生蛋白2(BMP2)对原发性肝癌(PHC)的诊断价值.方法:对70例慢性肝病患者及17例正常对照者血清进行检测,并按临床诊断或病理诊断分组,其中慢性病毒性肝炎20例,肝炎后肝硬化20例,PHC 30例.分别用酶联免疫法检测血清BMP2,用放射免疫法测定血清甲胎蛋白(AFP),结果:肝癌组患者血清BMP2较正常对照组、肝炎组、肝硬化组降低,且差异均有统计学意义(P<0.05);BMP2诊断PHC的敏感性是90%,特异性是100%,准确率是96.55%;BMP2诊断PHC的敏感性高于AFP(x2=22.78,P=0.001).结论:血清BMP2对PHC的诊断具有一定的价值. |
| 关 键 词： | 骨形态发生蛋白2 原发性肝癌 诊断 |
Expression of serum bone morphogenetic protein 2 in patients with primary hepatic carcinoma |
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| Biao Wen,Jun-Jie Mi,Tao-Hua Hou,Xiao-Hong Guo,Chun-Ai Bai,Cui-Ping Xu. Expression of serum bone morphogenetic protein 2 in patients with primary hepatic carcinoma[J]. World Chinese Journal of Digestology, 2010, 18(4) | |
| Authors: | Biao Wen Jun-Jie Mi Tao-Hua Hou Xiao-Hong Guo Chun-Ai Bai Cui-Ping Xu |
| Affiliation: | Biao Wen,Jun-Jie Mi,Tao-Hua Hou,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China Xiao-Hong Guo,Department of Experimental Center of Science , Research,the First Hospital of Shanxi Medical University,China Chun-Ai Bai,Office of Science , Technology,China Cui-Ping Xu,Department of Gastroenterology,China |
| Abstract: | AIM:To investigate the diagnostic value of serum bone morphogenetic protein 2(BMP2)in patients with primary hepatic carcinoma(PHC) by measuring serum BMP2 levels in patients with chronic liver disease.METHODS:Seventy serum samples,including20 from patients with chronic hepatitis,20 from those with hepatic cirrhosis and 30 from those with PHC,were detected in the study.Seventeen serum samples from normal donors were used as normal controls.The serum level of BMP2 was measured by enzyme-linked immunosorbent a... |
| Keywords: | Bone morphogenetic protein 2 Hepatic carcinoma Diagnosis |
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