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肝动脉化疗栓塞术治疗中晚期原发性肝癌的疗效观察
引用本文:纪昌林,杨润芝,肖绍树. 肝动脉化疗栓塞术治疗中晚期原发性肝癌的疗效观察[J]. 临床消化病杂志, 2014, 0(1): 40-43
作者姓名:纪昌林  杨润芝  肖绍树
作者单位:黄石市第五医院消化内科,湖北黄石435005
摘    要:[目的]研究经导管肝动脉化疗栓塞术(TACE)治疗中晚期原发性肝癌的疗效并预测影响患者生存率的相关因素。[方法]80例中晚期原发性肝癌患者经1次或多次TACE治疗后,分别于治疗后第1、3、6、12个月对患者进行CT扫描评估肿瘤对治疗的反应并计算生存率。[结果]对所有患者随访观察3年(或者观察至死亡),80例患者共进行了163次TACE,按Child-pugh分级A级48例(60.0%),B级32例(40.0%);肿瘤大小5cm 18例(22.5%),5~10cm 42例(52.5%),10cm 20例(25.0%);行1、2、3、4次TACE的患者分别为12、56、9、3例;1、2、3年的总生存率分别为71.3%、43.8%和17.5%,肿瘤直径5cm患者TACE后3年生存率显著高于肿瘤直径为5~≥10cm患者。[结论]TACE是治疗中晚期肝癌的一种有效的方法,能有效缓解患者的临床症状并延长生存期,初始肿瘤的大小是决定患者生存率的独立影响因素。

关 键 词:原发性肝癌  生存率  肝动脉化疗栓塞术

An observation of the curative effect of transcatheter arterial chemoembolization in patients with unresectable hepatocellular carcinoma
Affiliation:JI Chang-lin ,YANG Run-zhi , XIAO Skao-shu (Department of Gastroenterology, the Fifth Poeple' Hospital of Huangshi City 435005,China)
Abstract:[Objective] To investigate the outcome following transcatheter arterial chemoembolization (TACE)and to identify the predictors of survival in patients with unresetable hepatocellular carcinoma (HCC). [Methods] Eighty HCC patients get clinical,biochemical and radiological examination befrom TA- CE. TACE was performed in those who fulfilled the inclusion criterial follow-up assessment was done with CT scan of the liver at 1,3,6,and 12 months therapeutic effect tumor response and survival rate were estimated. Univariate analyses were done for determinations of survival. [Results]eighty patients were subjected to 163 sessions of TACE. The Child's classification was. A 48 patients (60%)and B 32 patients (40%). Tumor size was≤Scm in 18 (22. 5%) patients,〉5-10 cm in 42(52.5%) patients,and 〉10 cm in 20 (25 %) patients. 12,56,9,3patients were subjected to 1,2,3,4 sessions of TACE respectively, Overall survival rate was 71.3% ,43.8% and 17.5% at 1,2 and 3 years,respectively. Tumor size energed as an important predictor of survival. Conclution: TACE offers a reasonable palliative therapy for HCC. Initial tumor size is an independent predictor of survival.
Keywords:hepotocellular carcinoma  survival rate  transcatheter arterial chemoembolization
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