Blood screening for non-A, non-B hepatitis by hepatitis C virus antibody assay |
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| Authors: | T Katayama, S Kikuchi, Y Tanaka, I Saito, T Miyamura, QL Choo, M Houghton, G Kuo |
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| Affiliation: | Department of Surgery, Tokyo National Chest Hospital, Japan. |
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| Abstract: | Hepatitis C virus (HCV) antibody was detected in 1499 donor sera by radioimmunoassay using an antigen expressed in yeast from a cDNA clone of the HCV genome. Eighteen samples over 4200 counts per minute (cpm) were considered to contain infectious HCV because these recipients developed typical posttransfusion non-A, non-B hepatitis after transfusion. The antibody-positive sera were all within the normal range of ALT levels. This assay system is thus useful for the screening for blood transfusion. |
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