| 胃宁胶囊对胃溃疡大鼠胃黏膜EGF及EGFR mRNA表达的影响 |
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| 引用本文： | 刘敬,赵斌,王琼,谢朝良. 胃宁胶囊对胃溃疡大鼠胃黏膜EGF及EGFR mRNA表达的影响[J]. 中药与临床, 2012, 3(3): 34-36 |
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| 作者姓名： | 刘敬 赵斌 王琼 谢朝良 |
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| 作者单位： | 中山火炬职业技术学院生物医药系,广东 中山,528436 |
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| 摘 要： | 目的:探讨胃宁胶囊抗溃疡的作用机理.方法:采用大鼠幽门结扎法致胃溃疡模型；RT-PCR法观察胃宁胶囊对大鼠胃黏膜表皮生长因子(EGF)及表皮生长因子受体(EGFR) mRNA表达水平的影响.结果:胃宁胶囊能提高胃黏膜组织中EGF及EGFR mRNA的表达水平.结论:胃宁胶囊对胃黏膜的保护作用与提高胃黏膜组织中EGF及EGFR mRNA表达水平有关.
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| 关 键 词： | 胃宁胶囊 胃溃疡 表皮生长因子 表皮生长因子受体 |
Effects of Weining capsule on the expression of EGF and EGFR mRNA of gastric mucosa in experimental gastric ulcer rats |
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| LIU Jing , ZHAO Bin , WANG Qiong , XIE Chao-liang. Effects of Weining capsule on the expression of EGF and EGFR mRNA of gastric mucosa in experimental gastric ulcer rats[J]. Pharmacy and Clinics of Chinese Materia Medica, 2012, 3(3): 34-36 |
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| Authors: | LIU Jing ZHAO Bin WANG Qiong XIE Chao-liang |
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| Affiliation: | (Department of Biomedicine,Zhongshan Torch Polytechnic,Zhongshan 528436,Guangdong) |
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| Abstract: | Objective:To study the anti-ulcer mechanism of Weining capsule.Method:The gastric ulcer models were established by pyloric ligation.The effects of Weining capsule on the expression of EGF and EGFR mRNA of stomach mucous membrane in experimental gastric ulcer rats were investigated by RT-PCR method.Result:Weining capsule can increase the expression levels of EGF and EGFR mRNA of gastric mucosa.Conclusion:The study shows that the mechanism of Weining capsule in inhibiting the gastric ulcer has relation to the increase of the expression levels of EGF and EGFR mRNA of gastric mucosa. |
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| Keywords: | Weining capsule gastric ulcer EGF EGFR |
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