儿童先天性心脏病室间隔缺损致病因素分析

目的 :对儿童先天性室间隔缺损因素进行分析。方法 :报告 2 5 8例先天性室间隔缺损儿童 ,男性 14 4例 ,女性 114例 ,年龄 1～ 14岁。同时对 2 5 8例儿童的父母进行调查 ,调查对象为患先天性室间隔缺损儿童 ,儿童的父亲、母亲孕前和孕期多方面因素 ,将引起室间隔缺损的可能原因进行分析。结果 :发现家族中有遗传史 ,父母亲饮酒史 ,母孕期有感冒病史 ,母孕期服用抗病毒药物 ,父母孕期使用黄体酮及母孕期接触X射线 ,有较高先天性室间隔缺损的发病率。同时对患先天性室间隔缺损儿童血型分析 ,表明A型儿童和AB型儿童患先天性室间隔缺损频率较高 (分别为 4 2 2 5 %和 11 2 4 % )比值比(OR)分别为 1 6 3和 2 2 1。与对照组比较差异有显著性 (即A型 χ2 =7.0 2 ,P <0 0 0 1,AB型 χ2 =5 71,P <0 .0 5 )。A O ,AB O抗原患者组与对照组比较 ,OR分别为 1 72和 2 6 2 ,χ2 值分别为 6 72和 7 5 1均差异有显著性 (P <0 .0 0 1) ,而O型则相反患先天性室间隔缺损的机率相对减少。结论 :先天性室间隔缺损与家族遗传史、血型及父母孕期饮酒、服药等多方面因素有关。

The analysis of child congenital ventricular septal defect factors

Objective:To analyze child congenital ventricular septal defect(VSD)factors.Method:Report 258 child patients (144 male and 114 female) with congenital ventricular septal defect(VSD).The patients ranged in age from 1 year to 14 years.We investigated 258 child patients with congenital ventricular septal defect(VSD) and their mothers and facthers before and during pregnancy to analyze the risk factors.Result:Our investigation strongly suggested the existence of a family inheritance fator,mothers and fathers drinking alcohol during pregnancy,catching cold and taking autivirals and using progesterone and exposure x\|ray during pregnancy.These risk factors caused a high incidence of congenital ventricular septal defect.Analyzing the distribution with the ABO blood groups with child congenital ventricular septal defect.Higher congenital ventricular septal defect disease incidence was recorded in child patients with the A blood and the AB blood (42.25% and 11.24% respectively)Odds ratio was 1.63 and 2.21 respectively,comparison showed highly significant difference in both groups(The A blood chi-squares 7.02,P less than 0 001 the AB blood chi-squares 5.71 P less than 0.05).Comparison showed the existence of a direct relation between blood group antigens.Comparison the A blood group antigens and the AB blood antigens with the O blood group antigens,Odds ratio 1.72 and 2.62 respectively,chi-squares 6.72 and 7.51,showing significant difference(P less than 0 001).But the O blood was least incidence of congenital ventricular septal defect.Conclusion:The incidence of congenital ventricular septal defect is related to a family in heritance factor,ABO blood groups,drinking and taking modicine during pregnancy et al.