Radiologic progression of rheumatoid arthritis lesions treated with methotrexate

Methotrexate is the treatment of reference in rheumatoid arthritis (RA) because it has proved effective in this pathology. Its clinical efficacy is largely admitted but its radiological efficacy is still in certain. The other aim is to look for other clinical and radiological indices that influence these score evolution in patients treated by Methotrexate. Our study is an open prospective study about thirty RA defined about ACR criterions that don't receive other treatment followed up for 6 months. The methotrexate is administered at least 12 months (12 to 72 months) we evaluate its efficacy by Larsen score and Cohin indices. Remission has been reported in 80% of patients according to Larsen score and in 63.3% of patients according to Cohin indices. Its more efficace if admitted as a first treatment and for at least 12 months in young patients (under 40 years) with an arthritis evolution below 10 years and is at stage 0 or 1 of steinbroker but these data are not statistically significant first for patient age and ancientness of RA.