Clinical electrophysiology of the optic nerve and retinal ganglion cells |
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| Authors: | Oliver R. Marmoy Suresh Viswanathan |
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| Affiliation: | 1.Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children, London, UK ;2.UCL-GOS Institute for Child Health, University College London, London, UK ;3.Manchester Metropolitan University, Manchester, UK ;4.College of Optometry, State University of New York, New York, NY USA |
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| Abstract: | Clinical electrophysiological assessment of optic nerve and retinal ganglion cell function can be performed using the Pattern Electroretinogram (PERG), Visual Evoked Potential (VEP) and the Photopic Negative Response (PhNR) amongst other more specialised techniques. In this review, we describe these electrophysiological techniques and their application in diseases affecting the optic nerve and retinal ganglion cells with the exception of glaucoma. The disease groups discussed include hereditary, compressive, toxic/nutritional, traumatic, vascular, inflammatory and intracranial causes for optic nerve or retinal ganglion cell dysfunction. The benefits of objective, electrophysiological measurement of the retinal ganglion cells and optic nerve are discussed, as are their applications in clinical diagnosis of disease, determining prognosis, monitoring progression and response to novel therapies.Subject terms: Optic nerve diseases, Retina |
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