中性粒细胞胞外诱捕网在创面愈合过程中作用的研究进展

创面愈合与免疫及炎症反应密切相关。中性粒细胞作为炎症反应的主要效应细胞之一,已被证明在糖尿病足等创面愈合的病理生理过程中起着重要的作用。尤其是新近研究发现中性粒细胞在炎症、损伤等的刺激下,可以通过释放中性粒细胞胞外诱捕网(NET),抑制或阻碍创面的愈合,在创面愈合过程中起着重要的作用。然而,NET在不同类型的创面愈合中的作用还未完全阐明。本文将围绕免疫反应与炎症反应等在创面愈合中的最新研究进展,就NET在不同类型的创面愈合过程中的作用作一综述。

Research progress on the effect of neutrophil extracellular traps in wound healing

Wound healing is closely related to immunity and inflammation.As one of the main effector cells of inflammation,neutrophils have been proved to play an important role in the pathophysiological process of diabetic foot and other types of wound healing.Recent studies have proven that neutrophils can inhibit or hinder wound healing by releasing neutrophil extracellular trap(NET)under the stimulation of inflammation and injury,and play an important role in the process of wound healing.However,the role of NET in different types of wound healing has not been fully elucidated.This article will focus on the latest research progress of immune response and inflammatory response in wound healing,combined with the role of NET in the wound healing of different types to make a review.