广东省40岁及以上居民血压及超重/肥胖对糖尿病的影响

目的  探讨高血压、超重/肥胖及二者相加交互作用对糖尿病的影响，为预防糖尿病提供依据。方法  采用多阶段整群随机抽样方法，于2015年9-11月对8 991名居民进行问卷调查、医学体检及采集静脉血。基于复杂抽样构建Logistic回归分析模型及线性回归模型对数据进行统计分析，应用相加模型分析高血压及超重/肥胖对糖尿病患病的交互作用。结果  Logistic回归分析模型结果显示高血压和超重/肥胖是40岁及以上居民糖尿病的危险因素。相加模型结果显示，高血压和超重/肥胖对糖尿病存在协同作用，OR值为4.45(95% CI: 2.75~7.20)。交互作用对FPG及糖化血红蛋白的影响也大于单独高血压或超重/肥胖人群。结论  高血压、超重/肥胖是广东省40岁及以上人群糖尿病的独立危险因素，高血压伴有超重/肥胖对糖尿病患病存在相加交互作用。

The influence of blood pressure and overweight or obesity on diabetes mellitus among residents aged 40 years and above in Guangdong Province

  Objective  To explore the influence of hypertension, overweight/obesity, and their interaction effects on diabetes, so as to provide reference for preventing the occurrence of diabetes.  Methods  A multi-stage cluster random sampling method was adopted in this study, and 8 991 residents from September to November 2015, were selected for questionnaire survey, medical examination and venous blood collection. Logistic regression model and linear regression model were constructed based on complex sampling to analyze the data, and the additive model was used to analyze the interaction effect of hypertension and overweight/obesity on the prevalence of diabetes.  Results  Logistic regression results showed that hypertension and overweight/obesity were risk factors for diabetes in people aged ≥40 years. The results of the additive model showed that hypertension and overweight/obesity had a synergistic effect on diabetes, with the OR value of 4.45 (95% CI: 2.75-7.20). The interaction effect on fasting blood glucose and glycosylated hemoglobin was also greater than that of individuals with hypertension or overweight/obese alone.  Conclusions  Hypertension and overweight/obesity were independent risk factors for diabetes in people aged 40 years and over in Guangdong Province. Hypertension and overweight/obesity had additive interaction effects on diabetes.