脂质蓄积指数与糖尿病患病风险的关系

目的 探讨脂质蓄积指数(lipid accumulation product,LAP)与糖尿病患病风险的关系,并比较不同肥胖评价指标对糖尿病患病风险的预测价值.方法 2016年6月-2017年12月,采取多阶段分层整群抽样的方法,选择上海市松江区4个社区20～74岁常住居民作为研究对象,对其进行问卷调查及体格、生化检查...

The relationship between lipid accumulation product and the risk of diabetes

Objective To explore the relationship between lipid accumulation product(LAP) and the risk of diabetes among adults, and to compare the effectiveness of different obesity indicators in predicting diabetes. Methods A multi-stage stratified cluster sampling method was conducted among adults aged 20-74 in 4 communities in Songjiang District of Shanghai during June 2016 to December 2017. Questionnaire investigation, physical and biochemical examination were used to collect data. Logistic regression analysis models were used to evaluate the association LAP and diabetes, and receiver operating characteristics curve(ROC) was used to evaluate the predictive value of various obesity indicators in diabetes. Results The level of fasting blood glucose and HbA1 c was increased with the increasing of LAP(P<0. 05). Compared to the first quintile of LAP level, risk of having diabetes in the fourth quintile were 1.81 times(95% CI: 1.53-2.14) for male and 2.87 times(95% CI: 2.43-3.40) for female respectively. The predictive value of LAP was higher than BMI(P<0.05) both in male and female. It was also higher than waist circumference in female(P<0.05). The cut-off point for LAP in predicting diabetes was 23.30 cm·mmol/L for male and 30.41 cm·mmol/L for female. Conclusion LAP could be used to predict the risk of diabetes, especially in women.