| 胃癌组织中VEGF、HER-2/neu的研究 |
| |
| 引用本文： | 陈锦章,陈斌,郑航,黄宇贤,罗荣城.胃癌组织中VEGF、HER-2/neu的研究[J].山东医药,2008,48(32):13-15. |
| |
| 作者姓名： | 陈锦章 陈斌 郑航 黄宇贤 罗荣城 |
| |
| 作者单位： | 南方医科大学南方医院,广东,广州510515 |
| |
| 摘 要： | 目的 研究血管内皮生长因子(VEGF)和表皮生长因子受体2(HER-2/neu)在胃腺癌组织中的表达及其与胃癌各临床病理特征、胃癌患者生存期之间的关系.方法 通过回顾性研究,随访到有103例完整生存期的胃癌患者,应用免疫组化方法检测他们标本中VEGF、HER-2/neu的表达,并应用统计学方法分析检测结果与临床病理特征、生存期之间的关系.结果 胃癌组织中VEGF、HER-2/neu的阳性表达率分别为46.6%、31.1%,胃正常组织中二者均无表达;VEGF、HER-2/neu表达与肿瘤的浸润深度、病理分期、淋巴结转移、远处转移相关(P<0.05);VEGF与HER-2/neu阳性表达与生存期相关.结论 检测胃癌组织中VEGF、HER-2/neu表达有助于临床判断患者预后.
|
| 关 键 词： | 胃肿瘤 血管内皮生长因子 受体 表皮生长因子 靶向治疗 |
Study of VEGF and HER-2/neu in gastric cancer |
| |
| CHEN Jin-zhang,CHEN Bin,ZHENG Hang,HUANG Yu-xian,LUO Rong-cheng.Study of VEGF and HER-2/neu in gastric cancer[J].Shandong Medical Journal,2008,48(32):13-15. |
| |
| Authors: | CHEN Jin-zhang CHEN Bin ZHENG Hang HUANG Yu-xian LUO Rong-cheng |
| |
| Institution: | CHEN Jin-zhang,CHEN Bin,ZHENG Hang,HUANG Yu-xian,LUO Rong-cheng(Nanfang Hospital Southern Medical University,Guangzhou 510515,P.R.China) |
| |
| Abstract: | Objective To investigate the expression of vascular endothelial growth factor(VEGF) and epidermal growth factor receptor 2(HER-2) in gastric cancer and their relationship with clinical pathologic character and with survival.Methods The expression of VEGF and HER-2/neu in gastric cancer were studied by immunohistochemical technique.Their detect outcome and clinical pathologic character were analyzed.Results In gastric cancer specimens,the positive rate of VEGF and HER-2/neu was 46.6% and 31.1% respectively.T... |
| |
| Keywords: | gastric cancer vascular endothelial growth factor receptor epidermal growth factor targeted therapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
