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The effect of oral calcium carbonate administration on serum lipoproteins of children with familial hypercholesterolaemia (type II-A) |
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| Authors: | P. H. E. Groot W. F. A. Grose R. Dijkhuis-Stoffelsma J. Fernandes J. J. Ambagtsheer |
| Affiliation: | (1) Department of Biochemistry I, Medical Faculty, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands;(2) Department of Clinical Chemistry, Sophia Children's Hospital and Neonatal Unit, Erasmus University Rotterdam, The Netherlands;(3) Department of Paediatrics, Sophia Children's Hospital and Neonatal Unit, Erasmus University Rotterdam, The Netherlands;(4) Present address: Department of Paediatrics, State University Groningen, Groningen, The Netherlands |
| Abstract: | The effect of oral calcium carbonate on serum lipoprotein concentrations was tested in 50 children with familial hypercholesterolemia (type II-A) consuming a low cholesterol high polyunsaturated fat diet, using a cross-over design versus a placebo. Cholesterol was measured in serum and in the individual lipoprotein density classes. Serum apolipoprotein B (the protein moiety of low density lipoprotein) and apolipoprotein A-I (the main protein of high density lipoprotein) were measured by specific immunoassays. Calcium carbonate treatment induced only a slight increase in serum apolipoprotein A-I (+4%) and a slight decrease in low density lipoprotein cholesterol (-4%), both changes being significant at the P=0.05 level. |
| Keywords: | Calcium carbonate Lipoproteins Familial hypercholesterolemia Apolipoprotein A-I Apolipoprotein B |
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